Establishment of cell lines from the human middle and inner ear epithelial cells

David J. Lim, Sung K. Moon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations


The middle ear infection is the most common childhood infection. In order to elucidate the cell and molecular mechanisms involved in bacterial recognition and innate immune response, we have established a stable human middle ear cell line, which has contributed to the current knowledge concerning the molecular pathogenesis of the middle ear infection. The inner ear, a sensory organ responsible for hearing and balance, is filled with inner ear fluid, and disturbance of the fluid homeostasis results in dizziness and hearing impairment. It has been suggested that the endolymphatic sac (ES) may play a critical role in the fluid homeostasis of the inner ear. We have established a stable human ES cell line and are undertaking cell and molecular characterization of this cell line.

Original languageEnglish (US)
Title of host publicationHuman Cell Transformation
Subtitle of host publicationRole of Stem Cells and the Microenvironment
EditorsJohng Rhim, Richard Kremer
Number of pages11
StatePublished - 2011

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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