Essential lymphocyte function associated 1 (LFA-1): Intercellular adhesion molecule interactions for T cell-mediated B cell apoptosis by Fas/APO-1/CD95

Jin Wang, Michael J. Lenardo

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

B cells are susceptible to Fas ligand (FasL)+ CD4+ Th1 cell-mediated apoptosis. We demonstrate that blocking the interactions between lymphocyte function associated (LFA)-1 and intercellular adhesion molecule (ICAM)-1 and ICAM-2 completely suppresses Fas-dependent B cell lysis. Antibodies to CD2 and CD48 partially suppress B cell apoptosis, whereas anti-B7.1 and anti- B7.2 antibodies have no effect. Also, B cells from ICAM-1-deficient mice are resistant to FasL+ T cell-mediated death. Our results suggest that LFA- 1/ICAM interactions are crucial for Th1 cell-mediated B cell apoptosis and may contribute to the maintenance of B cell homeostasis in vivo.

Original languageEnglish (US)
Pages (from-to)1171-1176
Number of pages6
JournalJournal of Experimental Medicine
Volume186
Issue number7
DOIs
StatePublished - Oct 6 1997

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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