@article{0b356750c0c9431b89cd7b7220c9141b,
title = "Erythropoietin Stimulates Tumor Growth via EphB4",
abstract = "While recombinant human erythropoietin (rhEpo) has been widely used to treat anemia in cancer patients, concerns about its adverse effects on patient survival have emerged. A lack of correlation between expression of the canonical EpoR and rhEpo's effects on cancer cells prompted us to consider the existence of an alternative Epo receptor. Here, we identified EphB4 as an Epo receptor that triggers downstream signaling via STAT3 and promotes rhEpo-induced tumor growth and progression. In human ovarian and breast cancer samples, expression of EphB4 rather than the canonical EpoR correlated with decreased disease-specific survival in rhEpo-treated patients. These results identify EphB4 as a critical mediator of erythropoietin-induced tumor progression and further provide clinically significant dimension to the biology of erythropoietin.",
author = "Sunila Pradeep and Jie Huang and Mora, {Edna M.} and Nick, {Alpa M.} and Cho, {Min Soon} and Wu, {Sherry Y.} and Kyunghee Noh and Pecot, {Chad V.} and Rajesha Rupaimoole and Stein, {Martin A.} and Stephan Brock and Yunfei Wen and Chiyi Xiong and Kshipra Gharpure and Hansen, {Jean M.} and Nagaraja, {Archana S.} and Previs, {Rebecca A.} and Pablo Vivas-Mejia and Han, {Hee Dong} and Wei Hu and Mangala, {Lingegowda S.} and Behrouz Zand and Stagg, {Loren J.} and Ladbury, {John E.} and Bulent Ozpolat and Alpay, {S. Neslihan} and Masato Nishimura and Stone, {Rebecca L.} and Koji Matsuo and Armaiz-Pe{\~n}a, {Guillermo N.} and Dalton, {Heather J.} and Christopher Danes and Blake Goodman and Cristian Rodriguez-Aguayo and Carola Kruger and Armin Schneider and Shyon Haghpeykar and Padmavathi Jaladurgam and Hung, {Mien Chie} and Coleman, {Robert L.} and Jinsong Liu and Chun Li and Diana Urbauer and Gabriel Lopez-Berestein and Jackson, {David B.} and Sood, {Anil K.}",
note = "Funding Information: We thank Carmen Cruz, Cristina Castro, and Belisa Suarez for the collection of breast tumor samples and data. We also thank Dr. Rene Nieves Alicea, Dr. Mario Quintero, Nicholas Jennings, Donna Reynolds, Francesca Diella, Drs. Ramos, and Bharat B. Aggarwal for helpful discussion and guidance and Rahul Mitra for admistrative assistance. Portions of this work were supported by Molecular Health , the NIH ( CA 109298 , P50 CA083639 , P50 CA098258 , CA 177909 , U54CA151668 , UH2 TR000943 , CA 16672 , and U54 CA 096300 ), the Ovarian Cancer Research Fund (Program Project Development Grant), the DOD ( OC 120547 and OC 093416 ), CPRIT ( RP110595 and RPI 20214 ), the RGK Foundation , the Gilder Foundation , the Judi A. Rees Ovarian Cancer Research Fund , the Chapman Foundation , the Blanton-Davis Ovarian Cancer Research Program , and the Betty Anne Asche Murray Distinguished Professorship . A.M.N., B.Z., R.L.S., R.A.P., J.M.H., and H.J.D. were supported by NCI-DHHS-NIH T32 Training Grant ( T32 CA101642 ). K.M. was supported by the GCF/OCRF Ann Schreiber Ovarian Cancer Research grant and an award from the Meyer and Ida Gordon Foundation # 2 . L.J.S. and J.E.L. were supported by the G. Harold and Leila Y. Mathers Charitable Foundation . S.Y.W. was supported by the Ovarian Cancer Research Fund , the Foundation for Women{\textquoteright}s Cancer , and Cancer Prevention Research Institute of Texas training grants ( RP101502 , RP101489 , and RP110595 ). Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",
year = "2015",
month = nov,
day = "9",
doi = "10.1016/j.ccell.2015.09.008",
language = "English (US)",
volume = "28",
pages = "610--622",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "5",
}