Adducine érythrocytaire: Un régulateur structural de la membrane du globule rouge

Translated title of the contribution: Erythrocyte adducin: A structural regulator of the red blood cell membrane

T. Franco, P. S. Low

Research output: Contribution to journalShort survey

23 Scopus citations

Abstract

Adducin is an α, β heterotetramer that performs multiple important functions in the human erythrocyte membrane. First, adducin forms a bridge that connects the spectrin-actin junctional complex to band 3, the major membrane-spanning protein in the bilayer. Rupture of this bridge leads to membrane instability and spontaneous fragmentation. Second, adducin caps the fast growing (barbed) end of actin filaments, preventing the tetradecameric protofilaments from elongating into macroscopic F-actin microfilaments. Third, adducin stabilizes the association between actin and spectrin, assuring that the junctional complex remains intact during the mechanical distortions experienced by the circulating cell. And finally, adducin responds to stimuli that may be important in regulating the global properties of the cell, possibly including cation transport, cell morphology and membrane deformability. The text below summarizes the structural properties of adducin, its multiple functions in erythrocytes, and the consequences of engineered deletions of each of adducin subunits in transgenic mice.

Translated title of the contributionErythrocyte adducin: A structural regulator of the red blood cell membrane
Original languageFrench
Pages (from-to)87-94
Number of pages8
JournalTransfusion Clinique et Biologique
Volume17
Issue number3
DOIs
StatePublished - Sep 2010

Keywords

  • α-adducin
  • β-adducin
  • γ-adducin
  • Adducin's function
  • Adducin's regulation
  • Erythrocyte adducin
  • Erythrocyte membrane

ASJC Scopus subject areas

  • Hematology
  • Clinical Biochemistry
  • Biochemistry, medical

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