Error correcting models for functional characterization of deoxyribozymes

Elebeoba May

doi:10.1145/2800795.2800831

Error correcting models for functional characterization of deoxyribozymes

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

This material is based on work in progress. Naturally occurring and engineered nucleic acid based sensor and actuation systems are central to the function of wildtype organisms, synthetically engineered organisms, and engineered platforms used in a variety of biosensor applications. Molecular hybridization events govern the function and phenotypic outcome of these systems, and mutations in nucleic acids can impact system behavior. In this work we explore the use of coding theoretic constructs used for error correction to correlate quantifiable phenotypic outcome with position and category specific mutations in deoxyribozymes.

Original language	English (US)
Title of host publication	Proceedings of the 2nd ACM International Conference on Nanoscale Computing and Communication, ACM NANOCOM 2015
Publisher	Association for Computing Machinery, Inc
ISBN (Print)	9781450336741
DOIs	https://doi.org/10.1145/2800795.2800831
State	Published - Sep 21 2015
Event	2nd ACM International Conference on Nanoscale Computing and Communication, ACM NANOCOM 2015 - Boston, United States Duration: Sep 21 2015 → Sep 22 2015

Other

Other	2nd ACM International Conference on Nanoscale Computing and Communication, ACM NANOCOM 2015
Country/Territory	United States
City	Boston
Period	9/21/15 → 9/22/15

Keywords

Biosensors
Error control coding theory
Hybridization
Molecular beacons
Nucleotide polymorphism

ASJC Scopus subject areas

Computational Theory and Mathematics
Computer Networks and Communications
Communication

Access to Document

10.1145/2800795.2800831

Cite this

May, E 2015, Error correcting models for functional characterization of deoxyribozymes. in Proceedings of the 2nd ACM International Conference on Nanoscale Computing and Communication, ACM NANOCOM 2015., A22, Association for Computing Machinery, Inc, 2nd ACM International Conference on Nanoscale Computing and Communication, ACM NANOCOM 2015, Boston, United States, 9/21/15. https://doi.org/10.1145/2800795.2800831

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abstract = "This material is based on work in progress. Naturally occurring and engineered nucleic acid based sensor and actuation systems are central to the function of wildtype organisms, synthetically engineered organisms, and engineered platforms used in a variety of biosensor applications. Molecular hybridization events govern the function and phenotypic outcome of these systems, and mutations in nucleic acids can impact system behavior. In this work we explore the use of coding theoretic constructs used for error correction to correlate quantifiable phenotypic outcome with position and category specific mutations in deoxyribozymes.",

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AB - This material is based on work in progress. Naturally occurring and engineered nucleic acid based sensor and actuation systems are central to the function of wildtype organisms, synthetically engineered organisms, and engineered platforms used in a variety of biosensor applications. Molecular hybridization events govern the function and phenotypic outcome of these systems, and mutations in nucleic acids can impact system behavior. In this work we explore the use of coding theoretic constructs used for error correction to correlate quantifiable phenotypic outcome with position and category specific mutations in deoxyribozymes.

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KW - Error control coding theory

KW - Hybridization

KW - Molecular beacons

KW - Nucleotide polymorphism

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DO - 10.1145/2800795.2800831

M3 - Conference contribution

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BT - Proceedings of the 2nd ACM International Conference on Nanoscale Computing and Communication, ACM NANOCOM 2015

PB - Association for Computing Machinery, Inc

T2 - 2nd ACM International Conference on Nanoscale Computing and Communication, ACM NANOCOM 2015

Y2 - 21 September 2015 through 22 September 2015

ER -

Error correcting models for functional characterization of deoxyribozymes

Abstract

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Keywords

ASJC Scopus subject areas

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