Error correcting models for functional characterization of deoxyribozymes

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This material is based on work in progress. Naturally occurring and engineered nucleic acid based sensor and actuation systems are central to the function of wildtype organisms, synthetically engineered organisms, and engineered platforms used in a variety of biosensor applications. Molecular hybridization events govern the function and phenotypic outcome of these systems, and mutations in nucleic acids can impact system behavior. In this work we explore the use of coding theoretic constructs used for error correction to correlate quantifiable phenotypic outcome with position and category specific mutations in deoxyribozymes.

Original languageEnglish (US)
Title of host publicationProceedings of the 2nd ACM International Conference on Nanoscale Computing and Communication, ACM NANOCOM 2015
PublisherAssociation for Computing Machinery, Inc
ISBN (Print)9781450336741
DOIs
StatePublished - Sep 21 2015
Event2nd ACM International Conference on Nanoscale Computing and Communication, ACM NANOCOM 2015 - Boston, United States
Duration: Sep 21 2015Sep 22 2015

Other

Other2nd ACM International Conference on Nanoscale Computing and Communication, ACM NANOCOM 2015
CountryUnited States
CityBoston
Period9/21/159/22/15

Keywords

  • Biosensors
  • Error control coding theory
  • Hybridization
  • Molecular beacons
  • Nucleotide polymorphism

ASJC Scopus subject areas

  • Computational Theory and Mathematics
  • Computer Networks and Communications
  • Communication

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