Erratum to: Ephrin receptor A2 is an epithelial cell receptor for Epstein–Barr virus entry (Nature Microbiology, (2018), 3, 2, (164-171), 10.1038/s41564-017-0080-8)

Hua Zhang, Yan Li, Hong Bo Wang, Ao Zhang, Mei Ling Chen, Zhi Xin Fang, Xiao Dong Dong, Shi Bing Li, Yong Du, Dan Xiong, Jiang Yi He, Man Zhi Li, Yan Min Liu, Ai Jun Zhou, Qian Zhong, Yi Xin Zeng, Elliott Kieff, Zhiqiang Zhang, Benjamin E. Gewurz, Bo ZhaoMu Sheng Zeng

Research output: Contribution to journalComment/debate

2 Scopus citations

Abstract

In the version of this Letter originally published, the authors reported on the use of 2,5-dimethylpyrrolyl benzoic acid to block Ephrin receptors. In 2011, it was reported that newly synthesized 2,5-dimethylpyrrolyl benzoic acid lacked the previously reported EphA2 antagonizing activity1. However, the purchased compound did in fact have the activity initially reported, suggesting that an uncharacterized alteration occurred during storage. The authors therefore wish to clarify that the compound used in their study should be more accurately referred to as a 2,5-dimethylpyrrolyl benzoic acid derivative. All references to 2,5-dimethylpyrrolyl benzoic acid in the Letter have now been changed to reflect this. Although 2,5-dimethylpyrrolyl benzoic acid derivatives have been reported to have off-target effects2, as do most small-molecule inhibitors, the multiple complementary methods and techniques used demonstrate that EphA2 is a key Epstein–Barr virus epithelial cell receptor. The conclusions of the study are therefore unchanged.

Original languageEnglish (US)
Number of pages1
JournalNature Microbiology
Volume3
Issue number9
DOIs
StatePublished - Sep 1 2018

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Applied Microbiology and Biotechnology
  • Genetics
  • Microbiology (medical)
  • Cell Biology

Fingerprint Dive into the research topics of 'Erratum to: Ephrin receptor A2 is an epithelial cell receptor for Epstein–Barr virus entry (Nature Microbiology, (2018), 3, 2, (164-171), 10.1038/s41564-017-0080-8)'. Together they form a unique fingerprint.

Cite this