ERβ: Recent understanding of estrogen signaling

Nobuhiro Sugiyama, Rodrigo P.A. Barros, Margaret Warner, Jan Åke Gustafsson

Research output: Contribution to journalReview articlepeer-review

68 Scopus citations


The discovery of a second estrogen receptor, ERβ, and the finding that 5α-androstane-3β,17β-diol (3βAdiol) strongly binds to ERβ, have opened up a new aspect of estrogen signaling. Some of the major shifts in our understanding come from finding ERβ in tissues which do not express ERα but are estrogen-responsive; these were called sites of 'indirect estrogen action'. Two key sites that fall into this category are the brain and the prostate. Studies of ERβ in the past 10 years have led us to hypothesize that estrogen signaling depends on the balance between ERα and ERβ, and that inadequate predominance of one or the other isoform could lead to disease.

Original languageEnglish (US)
Pages (from-to)545-552
Number of pages8
JournalTrends in Endocrinology and Metabolism
Issue number9
StatePublished - Sep 2010

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


Dive into the research topics of 'ERβ: Recent understanding of estrogen signaling'. Together they form a unique fingerprint.

Cite this