Epstein–Barr Virus–Associated B-Cell Proliferations of Diverse Clonal Origins after Bone Marrow Transplantation in a 12-Year-Old Patient with Severe Combined Immunodeficiency

William T. Shearer; Jerome Ritz; Milton J. Finegold; I. Celine Guerra; Howard M. Rosenblatt; Dorothy E. Lewis; Marilyn S. Pollack; Larry H. Taber; Ciro V. Sumaya; F. Carl Grumet; Michael L. Cleary; Roger Warnke; Jeffrey Sklar

doi:10.1056/NEJM198505023121804

Epstein–Barr Virus–Associated B-Cell Proliferations of Diverse Clonal Origins after Bone Marrow Transplantation in a 12-Year-Old Patient with Severe Combined Immunodeficiency

William T. Shearer, Jerome Ritz, Milton J. Finegold, I. Celine Guerra, Howard M. Rosenblatt, Dorothy E. Lewis, Marilyn S. Pollack, Larry H. Taber, Ciro V. Sumaya, F. Carl Grumet, Michael L. Cleary, Roger Warnke, Jeffrey Sklar

Research output: Contribution to journal › Article › peer-review

165 Scopus citations

Abstract

The appearance of unregulated B-lymphocyte proliferations in organ-transplant recipients is a recent observation that has produced new concerns about the role of immunosuppressive agents and viruses in the development of neoplasia.¹ In particular, the detection of Epstein–Barr virus (EBV) or its genome in hyperplastic lymph nodes or in lymphoma-like growths in immunosuppressed transplant recipients suggests that the virus is a causative agent of the unregulated B-lymphocyte growth.² The controversy regarding the nature of these growths — i.e., whether they are neoplastic or hyperplastic — was recently studied in cardiac-allograft recipients by application of DNA-hybridization techniques. That analysis showed that lymphoproliferative.

Original language	English (US)
Pages (from-to)	1151-1159
Number of pages	9
Journal	New England Journal of Medicine
Volume	312
Issue number	18
DOIs	https://doi.org/10.1056/NEJM198505023121804
State	Published - May 2 1985

ASJC Scopus subject areas

General Medicine

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Shearer, W. T., Ritz, J., Finegold, M. J., Guerra, I. C., Rosenblatt, H. M., Lewis, D. E., Pollack, M. S., Taber, L. H., Sumaya, C. V., Grumet, F. C., Cleary, M. L., Warnke, R., & Sklar, J. (1985). Epstein–Barr Virus–Associated B-Cell Proliferations of Diverse Clonal Origins after Bone Marrow Transplantation in a 12-Year-Old Patient with Severe Combined Immunodeficiency. New England Journal of Medicine, 312(18), 1151-1159. https://doi.org/10.1056/NEJM198505023121804

Epstein–Barr Virus–Associated B-Cell Proliferations of Diverse Clonal Origins after Bone Marrow Transplantation in a 12-Year-Old Patient with Severe Combined Immunodeficiency. / Shearer, William T.; Ritz, Jerome; Finegold, Milton J. et al.
In: New England Journal of Medicine, Vol. 312, No. 18, 02.05.1985, p. 1151-1159.

Research output: Contribution to journal › Article › peer-review

Shearer, WT, Ritz, J, Finegold, MJ, Guerra, IC, Rosenblatt, HM, Lewis, DE, Pollack, MS, Taber, LH, Sumaya, CV, Grumet, FC, Cleary, ML, Warnke, R & Sklar, J 1985, 'Epstein–Barr Virus–Associated B-Cell Proliferations of Diverse Clonal Origins after Bone Marrow Transplantation in a 12-Year-Old Patient with Severe Combined Immunodeficiency', New England Journal of Medicine, vol. 312, no. 18, pp. 1151-1159. https://doi.org/10.1056/NEJM198505023121804

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abstract = "The appearance of unregulated B-lymphocyte proliferations in organ-transplant recipients is a recent observation that has produced new concerns about the role of immunosuppressive agents and viruses in the development of neoplasia.1 In particular, the detection of Epstein–Barr virus (EBV) or its genome in hyperplastic lymph nodes or in lymphoma-like growths in immunosuppressed transplant recipients suggests that the virus is a causative agent of the unregulated B-lymphocyte growth.2 The controversy regarding the nature of these growths — i.e., whether they are neoplastic or hyperplastic — was recently studied in cardiac-allograft recipients by application of DNA-hybridization techniques. That analysis showed that lymphoproliferative.",

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AU - Sumaya, Ciro V.

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AB - The appearance of unregulated B-lymphocyte proliferations in organ-transplant recipients is a recent observation that has produced new concerns about the role of immunosuppressive agents and viruses in the development of neoplasia.1 In particular, the detection of Epstein–Barr virus (EBV) or its genome in hyperplastic lymph nodes or in lymphoma-like growths in immunosuppressed transplant recipients suggests that the virus is a causative agent of the unregulated B-lymphocyte growth.2 The controversy regarding the nature of these growths — i.e., whether they are neoplastic or hyperplastic — was recently studied in cardiac-allograft recipients by application of DNA-hybridization techniques. That analysis showed that lymphoproliferative.

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Epstein–Barr Virus–Associated B-Cell Proliferations of Diverse Clonal Origins after Bone Marrow Transplantation in a 12-Year-Old Patient with Severe Combined Immunodeficiency

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