Abstract
The appearance of unregulated B-lymphocyte proliferations in organ-transplant recipients is a recent observation that has produced new concerns about the role of immunosuppressive agents and viruses in the development of neoplasia.1 In particular, the detection of Epstein–Barr virus (EBV) or its genome in hyperplastic lymph nodes or in lymphoma-like growths in immunosuppressed transplant recipients suggests that the virus is a causative agent of the unregulated B-lymphocyte growth.2 The controversy regarding the nature of these growths — i.e., whether they are neoplastic or hyperplastic — was recently studied in cardiac-allograft recipients by application of DNA-hybridization techniques. That analysis showed that lymphoproliferative.
Original language | English (US) |
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Pages (from-to) | 1151-1159 |
Number of pages | 9 |
Journal | New England Journal of Medicine |
Volume | 312 |
Issue number | 18 |
DOIs | |
State | Published - May 2 1985 |
ASJC Scopus subject areas
- General Medicine