Epstein-Barr virus-encoded latent membrane protein 1 modulates cyclin D1 by c-Jun/Jun B heterodimers

Xin Song, Yongguang Tao, Liang Zeng, Jing Yang, Faqing Tang, Leo M. Lee, Jianping Gong, Qiao Wu, Ya Cao

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

In our recent studies, we found that LMP1 encoded by Epstein-Barr virus could accelerate the formation of active c-Jun/Jun B heterodimer. We studied the regulation of cyclinD1 by c-Jun/Jun B heterodimers by laser scanning confocal influorescence microscopy, Western blot, luciferase activity assay, super-EMSA and flow cytometry in the Tet-on-LMP1 HNE2 cell line, in which LMP1 expression was regulated by Tet-on system. c-Jun/Jun B heterodimers induced by LMP1 could up regulate cyclin D1 promoter activity and expression. Overexpression of cyclinD1 accelerated the progression of cell cycle. Copyright by Science in China Press 2005.

Original languageEnglish (US)
Pages (from-to)385-393
Number of pages9
JournalScience in China, Series C: Life Sciences
Volume48
Issue number4
DOIs
StatePublished - Aug 2005

Keywords

  • Cell cycle
  • Cyclin D1
  • Heterodimer
  • Jun B
  • Latent membrane protein1
  • c-Jun

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

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