Epstein-Barr virus-encoded latent membrane protein 1 modulates cyclin D1 by c-Jun/Jun B heterodimers

Xin Song; Yongguang Tao; Liang Zeng; Jing Yang; Faqing Tang; Leo M. Lee; Jianping Gong; Qiao Wu; Ya Cao

doi:10.1360/03yc0251

Epstein-Barr virus-encoded latent membrane protein 1 modulates cyclin D1 by c-Jun/Jun B heterodimers

Xin Song, Yongguang Tao, Liang Zeng, Jing Yang, Faqing Tang, Leo M. Lee, Jianping Gong, Qiao Wu, Ya Cao

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

In our recent studies, we found that LMP1 encoded by Epstein-Barr virus could accelerate the formation of active c-Jun/Jun B heterodimer. We studied the regulation of cyclinD1 by c-Jun/Jun B heterodimers by laser scanning confocal influorescence microscopy, Western blot, luciferase activity assay, super-EMSA and flow cytometry in the Tet-on-LMP1 HNE2 cell line, in which LMP1 expression was regulated by Tet-on system. c-Jun/Jun B heterodimers induced by LMP1 could up regulate cyclin D1 promoter activity and expression. Overexpression of cyclinD1 accelerated the progression of cell cycle. Copyright by Science in China Press 2005.

Original language	English (US)
Pages (from-to)	385-393
Number of pages	9
Journal	Science in China, Series C: Life Sciences
Volume	48
Issue number	4
DOIs	https://doi.org/10.1360/03yc0251
State	Published - Aug 2005

Keywords

Cell cycle
Cyclin D1
Heterodimer
Jun B
Latent membrane protein1
c-Jun

ASJC Scopus subject areas

Renewable Energy, Sustainability and the Environment
Modeling and Simulation
Biochemistry, Genetics and Molecular Biology(all)
Fuel Technology
Environmental Science(all)
Energy Engineering and Power Technology
Agricultural and Biological Sciences(all)
Energy(all)
Management, Monitoring, Policy and Law

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title = "Epstein-Barr virus-encoded latent membrane protein 1 modulates cyclin D1 by c-Jun/Jun B heterodimers",

abstract = "In our recent studies, we found that LMP1 encoded by Epstein-Barr virus could accelerate the formation of active c-Jun/Jun B heterodimer. We studied the regulation of cyclinD1 by c-Jun/Jun B heterodimers by laser scanning confocal influorescence microscopy, Western blot, luciferase activity assay, super-EMSA and flow cytometry in the Tet-on-LMP1 HNE2 cell line, in which LMP1 expression was regulated by Tet-on system. c-Jun/Jun B heterodimers induced by LMP1 could up regulate cyclin D1 promoter activity and expression. Overexpression of cyclinD1 accelerated the progression of cell cycle. Copyright by Science in China Press 2005.",

keywords = "Cell cycle, Cyclin D1, Heterodimer, Jun B, Latent membrane protein1, c-Jun",

author = "Xin Song and Yongguang Tao and Liang Zeng and Jing Yang and Faqing Tang and Lee, {Leo M.} and Jianping Gong and Qiao Wu and Ya Cao",

note = "Funding Information: Acknowledgements This work was supported by the State Key Basic Research Program, Foundational Investigation on Human Carcinogenesis of China (Grant No. G1998051201), National Natural Science Foundation for Distinguished Young Scholars of China (Grant No. 39525022) and National Natural Science Foundation of China (Grant Nos. 30300403, 30100005 & 30000087).",

year = "2005",

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doi = "10.1360/03yc0251",

language = "English (US)",

volume = "48",

pages = "385--393",

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T1 - Epstein-Barr virus-encoded latent membrane protein 1 modulates cyclin D1 by c-Jun/Jun B heterodimers

AU - Song, Xin

AU - Tao, Yongguang

AU - Zeng, Liang

AU - Yang, Jing

AU - Tang, Faqing

AU - Lee, Leo M.

AU - Gong, Jianping

AU - Wu, Qiao

AU - Cao, Ya

N1 - Funding Information: Acknowledgements This work was supported by the State Key Basic Research Program, Foundational Investigation on Human Carcinogenesis of China (Grant No. G1998051201), National Natural Science Foundation for Distinguished Young Scholars of China (Grant No. 39525022) and National Natural Science Foundation of China (Grant Nos. 30300403, 30100005 & 30000087).

PY - 2005/8

Y1 - 2005/8

N2 - In our recent studies, we found that LMP1 encoded by Epstein-Barr virus could accelerate the formation of active c-Jun/Jun B heterodimer. We studied the regulation of cyclinD1 by c-Jun/Jun B heterodimers by laser scanning confocal influorescence microscopy, Western blot, luciferase activity assay, super-EMSA and flow cytometry in the Tet-on-LMP1 HNE2 cell line, in which LMP1 expression was regulated by Tet-on system. c-Jun/Jun B heterodimers induced by LMP1 could up regulate cyclin D1 promoter activity and expression. Overexpression of cyclinD1 accelerated the progression of cell cycle. Copyright by Science in China Press 2005.

AB - In our recent studies, we found that LMP1 encoded by Epstein-Barr virus could accelerate the formation of active c-Jun/Jun B heterodimer. We studied the regulation of cyclinD1 by c-Jun/Jun B heterodimers by laser scanning confocal influorescence microscopy, Western blot, luciferase activity assay, super-EMSA and flow cytometry in the Tet-on-LMP1 HNE2 cell line, in which LMP1 expression was regulated by Tet-on system. c-Jun/Jun B heterodimers induced by LMP1 could up regulate cyclin D1 promoter activity and expression. Overexpression of cyclinD1 accelerated the progression of cell cycle. Copyright by Science in China Press 2005.

KW - Cell cycle

KW - Cyclin D1

KW - Heterodimer

KW - Jun B

KW - Latent membrane protein1

KW - c-Jun

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Epstein-Barr virus-encoded latent membrane protein 1 modulates cyclin D1 by c-Jun/Jun B heterodimers

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ASJC Scopus subject areas

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