TY - JOUR
T1 - Epithelioid hemangioma of the penis. A rare and distinctive vascular lesion
AU - Srigley, J. R.
AU - Ayala, Alberto
AU - Ordonez, N. G.
AU - Van Nostrand, A. W.P.
PY - 1985/1/1
Y1 - 1985/1/1
N2 - Two patients, aged 36 and 47 years, respectively, had indurated subcutaneous penile nodules that were treated by local excision. Histologically, the lesions were characterized by cords and nests of plump epithelioid cells separated by a loose stroma containing numerous lymphocytes and eosinophils. Light microscopy identified definite vasoformative areas and solid regions with cytoplasmic vacuolization and nuclear atypia. Ultrastructural studies and immunohistochemical analysis for factor VIII-related antigen and Ulex europaeus agglutinin I demonstrated that the lesions were of endothelial origin. After excision of the nodules, the two patients are free of disease 5 1/2 and 6 1/2 years later, respectively. To our knowledge, a review of the literature produced only one similar case. These unusual vascular lesions, of undetermined cause, are proliferations of endothelial cells exhibiting an epithelioid structure that should be considered benign and treated locally.
AB - Two patients, aged 36 and 47 years, respectively, had indurated subcutaneous penile nodules that were treated by local excision. Histologically, the lesions were characterized by cords and nests of plump epithelioid cells separated by a loose stroma containing numerous lymphocytes and eosinophils. Light microscopy identified definite vasoformative areas and solid regions with cytoplasmic vacuolization and nuclear atypia. Ultrastructural studies and immunohistochemical analysis for factor VIII-related antigen and Ulex europaeus agglutinin I demonstrated that the lesions were of endothelial origin. After excision of the nodules, the two patients are free of disease 5 1/2 and 6 1/2 years later, respectively. To our knowledge, a review of the literature produced only one similar case. These unusual vascular lesions, of undetermined cause, are proliferations of endothelial cells exhibiting an epithelioid structure that should be considered benign and treated locally.
UR - http://www.scopus.com/inward/record.url?scp=0021877197&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021877197&partnerID=8YFLogxK
M3 - Article
C2 - 3838233
AN - SCOPUS:0021877197
SN - 0003-9985
VL - 109
SP - 51
EP - 54
JO - Archives of Pathology and Laboratory Medicine
JF - Archives of Pathology and Laboratory Medicine
IS - 1
ER -