Epithelial-Mesenchymal Plasticity in Organotropism Metastasis and Tumor Immune Escape

Xiang Nan; Jiang Wang; Haowen Nikola Liu; Stephen T C Wong; Hong Zhao

doi:10.3390/jcm8050747

Epithelial-Mesenchymal Plasticity in Organotropism Metastasis and Tumor Immune Escape

Xiang Nan, Jiang Wang, Haowen Nikola Liu, Stephen T C Wong, Hong Zhao

Research output: Contribution to journal › Review article › peer-review

Abstract

Most cancer deaths are due to metastasis, and almost all cancers have their preferential metastatic organs, known as "organotropism metastasis". Epithelial-mesenchymal plasticity has been described as heterogeneous and dynamic cellular differentiation states, supported by emerging experimental evidence from both molecular and morphological levels. Many molecular factors regulating epithelial-mesenchymal plasticity have tissue-specific and non-redundant properties. Reciprocally, cellular epithelial-mesenchymal plasticity contributes to shaping organ-specific pre-metastatic niche (PMN) including distinct local immune landscapes, mainly through secreted bioactive molecular factors. Here, we summarize recent progress on the involvement of tumor epithelial-mesenchymal plasticity in driving organotropic metastasis and regulating the function of different immune cells in organ-specific metastasis.

Original language	English (US)
Journal	journal of clinical medicine
Volume	8
Issue number	5
DOIs	https://doi.org/10.3390/jcm8050747
State	Published - May 25 2019

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title = "Epithelial-Mesenchymal Plasticity in Organotropism Metastasis and Tumor Immune Escape",

abstract = "Most cancer deaths are due to metastasis, and almost all cancers have their preferential metastatic organs, known as {"}organotropism metastasis{"}. Epithelial-mesenchymal plasticity has been described as heterogeneous and dynamic cellular differentiation states, supported by emerging experimental evidence from both molecular and morphological levels. Many molecular factors regulating epithelial-mesenchymal plasticity have tissue-specific and non-redundant properties. Reciprocally, cellular epithelial-mesenchymal plasticity contributes to shaping organ-specific pre-metastatic niche (PMN) including distinct local immune landscapes, mainly through secreted bioactive molecular factors. Here, we summarize recent progress on the involvement of tumor epithelial-mesenchymal plasticity in driving organotropic metastasis and regulating the function of different immune cells in organ-specific metastasis.",

author = "Xiang Nan and Jiang Wang and Liu, {Haowen Nikola} and Wong, {Stephen T C} and Hong Zhao",

year = "2019",

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language = "English (US)",

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T1 - Epithelial-Mesenchymal Plasticity in Organotropism Metastasis and Tumor Immune Escape

AU - Nan, Xiang

AU - Wang, Jiang

AU - Liu, Haowen Nikola

AU - Wong, Stephen T C

AU - Zhao, Hong

PY - 2019/5/25

Y1 - 2019/5/25

N2 - Most cancer deaths are due to metastasis, and almost all cancers have their preferential metastatic organs, known as "organotropism metastasis". Epithelial-mesenchymal plasticity has been described as heterogeneous and dynamic cellular differentiation states, supported by emerging experimental evidence from both molecular and morphological levels. Many molecular factors regulating epithelial-mesenchymal plasticity have tissue-specific and non-redundant properties. Reciprocally, cellular epithelial-mesenchymal plasticity contributes to shaping organ-specific pre-metastatic niche (PMN) including distinct local immune landscapes, mainly through secreted bioactive molecular factors. Here, we summarize recent progress on the involvement of tumor epithelial-mesenchymal plasticity in driving organotropic metastasis and regulating the function of different immune cells in organ-specific metastasis.

AB - Most cancer deaths are due to metastasis, and almost all cancers have their preferential metastatic organs, known as "organotropism metastasis". Epithelial-mesenchymal plasticity has been described as heterogeneous and dynamic cellular differentiation states, supported by emerging experimental evidence from both molecular and morphological levels. Many molecular factors regulating epithelial-mesenchymal plasticity have tissue-specific and non-redundant properties. Reciprocally, cellular epithelial-mesenchymal plasticity contributes to shaping organ-specific pre-metastatic niche (PMN) including distinct local immune landscapes, mainly through secreted bioactive molecular factors. Here, we summarize recent progress on the involvement of tumor epithelial-mesenchymal plasticity in driving organotropic metastasis and regulating the function of different immune cells in organ-specific metastasis.

U2 - 10.3390/jcm8050747

DO - 10.3390/jcm8050747

M3 - Review article

C2 - 31130637

SN - 2077-0383

VL - 8

JO - journal of clinical medicine

JF - journal of clinical medicine

IS - 5

ER -

Epithelial-Mesenchymal Plasticity in Organotropism Metastasis and Tumor Immune Escape

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