Epigenetic regulation of axonal regenerative capacity

Research output: Contribution to journalReview article

Yi Lan Weng, Jessica Joseph, Ran An, Hongjun Song, Guo Li Ming

The intrinsic growth capacity of neurons in the CNS declines during neuronal maturation, while neurons in the adult PNS are capable of regeneration. Injured mature PNS neurons require activation of an array of regeneration-associated genes to regain axonal growth competence. Accumulating evidence indicates a pivotal role of epigenetic mechanisms in transcriptional reprogramming and regulation of neuronal growth ability upon injury. In this review, we summarize the latest findings implicating epigenetic mechanisms, including histone and DNA modifications, in axon regeneration and discuss differential epigenomic configurations between neurons in the adult mammalian CNS and PNS.

Original languageEnglish (US)
Pages (from-to)1429-1442
Number of pages14
JournalEpigenomics
Volume8
Issue number10
DOIs
StatePublished - Oct 1 2016

PMID: 27642866

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Epigenetic regulation of axonal regenerative capacity. / Weng, Yi Lan; Joseph, Jessica; An, Ran; Song, Hongjun; Ming, Guo Li.

In: Epigenomics, Vol. 8, No. 10, 01.10.2016, p. 1429-1442.

Research output: Contribution to journalReview article

Harvard

Weng, YL, Joseph, J, An, R, Song, H & Ming, GL 2016, 'Epigenetic regulation of axonal regenerative capacity' Epigenomics, vol. 8, no. 10, pp. 1429-1442. https://doi.org/10.2217/epi-2016-0058

APA

Weng, Y. L., Joseph, J., An, R., Song, H., & Ming, G. L. (2016). Epigenetic regulation of axonal regenerative capacity. Epigenomics, 8(10), 1429-1442. https://doi.org/10.2217/epi-2016-0058

Vancouver

Weng YL, Joseph J, An R, Song H, Ming GL. Epigenetic regulation of axonal regenerative capacity. Epigenomics. 2016 Oct 1;8(10):1429-1442. https://doi.org/10.2217/epi-2016-0058

Author

Weng, Yi Lan ; Joseph, Jessica ; An, Ran ; Song, Hongjun ; Ming, Guo Li. / Epigenetic regulation of axonal regenerative capacity. In: Epigenomics. 2016 ; Vol. 8, No. 10. pp. 1429-1442.

BibTeX

@article{08a4680d59834ef99215777e952ace2a,
title = "Epigenetic regulation of axonal regenerative capacity",
abstract = "The intrinsic growth capacity of neurons in the CNS declines during neuronal maturation, while neurons in the adult PNS are capable of regeneration. Injured mature PNS neurons require activation of an array of regeneration-associated genes to regain axonal growth competence. Accumulating evidence indicates a pivotal role of epigenetic mechanisms in transcriptional reprogramming and regulation of neuronal growth ability upon injury. In this review, we summarize the latest findings implicating epigenetic mechanisms, including histone and DNA modifications, in axon regeneration and discuss differential epigenomic configurations between neurons in the adult mammalian CNS and PNS.",
keywords = "axon regeneration, DNA demethylation, DNA methylation, DNA methyltransferase, HDAC, histone deacetylase inhibitor, histone modification, TET family protein",
author = "Weng, {Yi Lan} and Jessica Joseph and Ran An and Hongjun Song and Ming, {Guo Li}",
year = "2016",
month = "10",
day = "1",
doi = "10.2217/epi-2016-0058",
language = "English (US)",
volume = "8",
pages = "1429--1442",
journal = "Epigenomics",
issn = "1750-1911",
publisher = "Future Medicine Ltd.",
number = "10",

}

RIS

TY - JOUR

T1 - Epigenetic regulation of axonal regenerative capacity

AU - Weng, Yi Lan

AU - Joseph, Jessica

AU - An, Ran

AU - Song, Hongjun

AU - Ming, Guo Li

PY - 2016/10/1

Y1 - 2016/10/1

N2 - The intrinsic growth capacity of neurons in the CNS declines during neuronal maturation, while neurons in the adult PNS are capable of regeneration. Injured mature PNS neurons require activation of an array of regeneration-associated genes to regain axonal growth competence. Accumulating evidence indicates a pivotal role of epigenetic mechanisms in transcriptional reprogramming and regulation of neuronal growth ability upon injury. In this review, we summarize the latest findings implicating epigenetic mechanisms, including histone and DNA modifications, in axon regeneration and discuss differential epigenomic configurations between neurons in the adult mammalian CNS and PNS.

AB - The intrinsic growth capacity of neurons in the CNS declines during neuronal maturation, while neurons in the adult PNS are capable of regeneration. Injured mature PNS neurons require activation of an array of regeneration-associated genes to regain axonal growth competence. Accumulating evidence indicates a pivotal role of epigenetic mechanisms in transcriptional reprogramming and regulation of neuronal growth ability upon injury. In this review, we summarize the latest findings implicating epigenetic mechanisms, including histone and DNA modifications, in axon regeneration and discuss differential epigenomic configurations between neurons in the adult mammalian CNS and PNS.

KW - axon regeneration

KW - DNA demethylation

KW - DNA methylation

KW - DNA methyltransferase

KW - HDAC

KW - histone deacetylase inhibitor

KW - histone modification

KW - TET family protein

UR - http://www.scopus.com/inward/record.url?scp=84990829361&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84990829361&partnerID=8YFLogxK

U2 - 10.2217/epi-2016-0058

DO - 10.2217/epi-2016-0058

M3 - Review article

VL - 8

SP - 1429

EP - 1442

JO - Epigenomics

T2 - Epigenomics

JF - Epigenomics

SN - 1750-1911

IS - 10

ER -

ID: 41875653