Epigenetic regulation of axonal regenerative capacity

Yi Lan Weng, Jessica Joseph, Ran An, Hongjun Song, Guo Li Ming

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

The intrinsic growth capacity of neurons in the CNS declines during neuronal maturation, while neurons in the adult PNS are capable of regeneration. Injured mature PNS neurons require activation of an array of regeneration-associated genes to regain axonal growth competence. Accumulating evidence indicates a pivotal role of epigenetic mechanisms in transcriptional reprogramming and regulation of neuronal growth ability upon injury. In this review, we summarize the latest findings implicating epigenetic mechanisms, including histone and DNA modifications, in axon regeneration and discuss differential epigenomic configurations between neurons in the adult mammalian CNS and PNS.

Original languageEnglish (US)
Pages (from-to)1429-1442
Number of pages14
JournalEpigenomics
Volume8
Issue number10
DOIs
StatePublished - Oct 1 2016

Keywords

  • axon regeneration
  • DNA demethylation
  • DNA methylation
  • DNA methyltransferase
  • HDAC
  • histone deacetylase inhibitor
  • histone modification
  • TET family protein

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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    Weng, Y. L., Joseph, J., An, R., Song, H., & Ming, G. L. (2016). Epigenetic regulation of axonal regenerative capacity. Epigenomics, 8(10), 1429-1442. https://doi.org/10.2217/epi-2016-0058