Epigenetic Regulation of Angiogenesis in Peripheral Artery Disease

Li Lai, Zhen Chen, Naseeb Kaur Malhi, Kevin W. Southerland

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Peripheral arterial disease (PAD) represents a global health concern with a rising prevalence attributed to factors such as obesity, diabetes, aging, and smoking. Among patients with PAD, chronic limb-threatening ischemia (CLTI) is the most severe manifestation, associated with substantial morbidity and mortality. While revascularization remains the primary therapy for CLTI, not all patients are candidates for such interventions, highlighting the need for alternative approaches. Impaired angiogenesis, the growth of new blood vessels, is a central feature of PAD, and despite decades of research, effective clinical treatments remain elusive. Epigenetics, the study of heritable changes in gene expression, has gained prominence in understanding PAD pathogenesis. Here, we explore the role of epigenetic regulation in angiogenesis within the context of PAD, with a focus on long non-coding RNAs and fibroblast-endothelial cell transdifferentiation. Additionally, we discuss the interplay between metabolic control and epigenetic regulation, providing insights into potential novel therapeutic avenues for improving PAD treatments. This review aims to offer a concise update on the application of epigenetics in angiogenesis and PAD research, inspiring further investigations in this promising field.

Original languageEnglish (US)
Pages (from-to)47-57
Number of pages11
JournalMethodist DeBakey cardiovascular journal
Volume19
Issue number5
DOIs
StatePublished - Nov 16 2023

Keywords

  • Epigenesis, Genetic
  • Humans
  • Ischemia/genetics
  • Peripheral Arterial Disease/genetics
  • angiogenesis
  • fibroblast-endothelial transdifferentiation
  • hindlimb ischemia (HLI)
  • long non-coding RNAs (lncRNAs)
  • peripheral arterial disease (PAD)
  • epigenetics

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint

Dive into the research topics of 'Epigenetic Regulation of Angiogenesis in Peripheral Artery Disease'. Together they form a unique fingerprint.

Cite this