Epigenetic modulation of human breast cancer by metallofullerenol nanoparticles: In vivo treatment and in vitro analysis

Jie Meng, Jianmin Xing, Yingze Wang, Juan Lu, Yuliang Zhao, Xueyun Gao, Paul C. Wang, Lee Jia, Xingjie Liang

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Multi-hydroxylated endohedral metallofullerenol [Gd@C 82(OH) 22] n nanoparticles possess the general physico-chemical characteristics of most nanoparticles. They also exhibit uniquely low toxicity and antineoplastic efficacy. In the current study, the molecular mechanisms and epigenetic characteristics of the antineoplastic action of these nanoparticles are explored. Human breast cancer MCF-7 and human umbilical vein endothelial ECV304 cell lines were used. Cell viability assay, cell hierarchical cluster analysis by cDNA microarray, semi-quantitative reverse transcription-polymerase chain reaction and Western blot analysis were conducted to investigate the changes in molecular and cellular signaling pathways caused by [Gd@C 82(OH) 22] n. The results demonstrated the high antitumor activity and low cytotoxicity of [Gd@C 82(OH) 22] n nanoparticles both in vivo and in vitro. Their possible anti-tumor mechanisms were also discussed. The present study may provide new insight into the mechanism of action of these nanoparticles.

Original languageEnglish (US)
Pages (from-to)4713-4719
Number of pages7
JournalNanoscale
Volume3
Issue number11
DOIs
StatePublished - Nov 1 2011

ASJC Scopus subject areas

  • Materials Science(all)

Fingerprint Dive into the research topics of 'Epigenetic modulation of human breast cancer by metallofullerenol nanoparticles: In vivo treatment and in vitro analysis'. Together they form a unique fingerprint.

Cite this