Epigenetic modifications of chronic hypoxia-mediated neurodegeneration in Alzheimer's disease

Hui Liu, Weidong Le

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disorder affecting the elderly people. AD is characterized by progressive and gradual decline in cognitive function and memory loss. While familial early-onset AD is usually associated with gene mutations, the etiology of sporadic late-onset form of AD is largely unknown. It has been reported that environmental factors and epigenetic alterations significantly contribute to the process of AD. Our previous studies have documented that chronic hypoxia is one of the environmental factors that may trigger the AD development and aggravate the disease progression. In this review, we will summarize the pathological effects of chronic hypoxia on the onset and development of AD and put forward the possible molecule mechanisms underlying the chronic hypoxia mediated AD pathogenesis. Finally, we propose that epigenetic regulations may represent new opportunity for the therapeutic intervention of this disease.

Original languageEnglish (US)
Article number7
JournalTranslational Neurodegeneration
Volume3
Issue number1
DOIs
StatePublished - Mar 20 2014

Keywords

  • Alzheimer's disease
  • Chronic hypoxia
  • DNA methylation
  • Epigenetic modification
  • Histone acetylation

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience

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