(-)-Epigallocatechin gallate inhibits lipopolysaccharide-induced microglial activation and protects against inflammation-mediated dopaminergic neuronal injury

Rui Li, Yuan Gui Huang, Du Fang, Weidong Le

Research output: Contribution to journalArticle

153 Scopus citations

Abstract

Microglial activation is believed to play a pivotal role in the selective neuronal injury associated with several neurodegenerative disorders, including Parkinson's disease (PD) and Alzheimer's disease. We provide evidence that (-)-epigallocatechin gallate (EGCG), a major monomer of green tea polyphenols, potently inhibits lipopolysaccharide (LPS)-activated microglial secretion of nitric oxide (NO) and tumor necrosis factor-α (TNF-α) through the down-regulation of inducible NO synthase and TNF-α expression. In addition, EGCG exerted significant protection against microglial activation-induced neuronal injury both in the human dopaminergic cell line SH-SY5Y and in primary rat mesencephalic cultures. Our study demonstrates that EGCG is a potent inhibitor of microglial activation and thus is a useful candidate for a therapeutic approach to alleviating microglia-mediated dopaminergic neuronal injury in PD.

Original languageEnglish (US)
Pages (from-to)723-731
Number of pages9
JournalJournal of Neuroscience Research
Volume78
Issue number5
DOIs
StatePublished - Dec 1 2004

Keywords

  • Green tea polyphenol
  • Nitric oxide
  • Parkinson disease
  • Tumor necrosis factor
  • Tyrosine hydroxylase

ASJC Scopus subject areas

  • Neuroscience(all)

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