Epidermal growth factor receptor (EGFR): Mutational and protein expression analysis in gastric cancer

Enzo Mammano, Claudio Belluco, Manuela Sciro, Roberto Mencarelli, Marco Agostini, Mauro Michelotto, Alberto Marchet, Donato Nitti

    Research output: Contribution to journalArticlepeer-review

    37 Scopus citations

    Abstract

    Background: Since specific epidermal growth factor receptor (EGFR) somatic mutations have been demonstrated to influence the response to anti-EGFR therapy in non-small cell lung cancer, EGFR gene mutational analysis of different types of neoplasm is under investigation. Patients and Methods: EGFR protein expression and gene mutations in exons 18, 19 and 21 were investigated in 49 gastric adenocarcinomas. Results: no specific EGFR gene mutations were detected, while EGFR positive staining was detected in 6% of the cases. Conclusion: Our findings indicate that in gastric adenocarcinoma, specific EGFR gene mutations are very rare or absent and the rate of EGFR protein expression is low.

    Original languageEnglish (US)
    Pages (from-to)3547-3550
    Number of pages4
    JournalAnticancer Research
    Volume26
    Issue number5 A
    StatePublished - Sep 1 2006

    Keywords

    • EGFR mutation
    • Epidermal growth factor receptor (EGFR)
    • Gastric cancer
    • Immunohistochemistry

    ASJC Scopus subject areas

    • Cancer Research
    • Oncology

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