Epidermal growth factor receptor (EGFR): Mutational and protein expression analysis in gastric cancer

Enzo Mammano; Claudio Belluco; Manuela Sciro; Roberto Mencarelli; Marco Agostini; Mauro Michelotto; Alberto Marchet; Donato Nitti

Epidermal growth factor receptor (EGFR): Mutational and protein expression analysis in gastric cancer

Enzo Mammano, Claudio Belluco, Manuela Sciro, Roberto Mencarelli, Marco Agostini, Mauro Michelotto, Alberto Marchet, Donato Nitti

Research Institute

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34 Scopus citations

Abstract

Background: Since specific epidermal growth factor receptor (EGFR) somatic mutations have been demonstrated to influence the response to anti-EGFR therapy in non-small cell lung cancer, EGFR gene mutational analysis of different types of neoplasm is under investigation. Patients and Methods: EGFR protein expression and gene mutations in exons 18, 19 and 21 were investigated in 49 gastric adenocarcinomas. Results: no specific EGFR gene mutations were detected, while EGFR positive staining was detected in 6% of the cases. Conclusion: Our findings indicate that in gastric adenocarcinoma, specific EGFR gene mutations are very rare or absent and the rate of EGFR protein expression is low.

Original language	English (US)
Pages (from-to)	3547-3550
Number of pages	4
Journal	Anticancer Research
Volume	26
Issue number	5 A
State	Published - Sep 1 2006

Keywords

EGFR mutation
Epidermal growth factor receptor (EGFR)
Gastric cancer
Immunohistochemistry

ASJC Scopus subject areas

Cancer Research
Oncology

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title = "Epidermal growth factor receptor (EGFR): Mutational and protein expression analysis in gastric cancer",

abstract = "Background: Since specific epidermal growth factor receptor (EGFR) somatic mutations have been demonstrated to influence the response to anti-EGFR therapy in non-small cell lung cancer, EGFR gene mutational analysis of different types of neoplasm is under investigation. Patients and Methods: EGFR protein expression and gene mutations in exons 18, 19 and 21 were investigated in 49 gastric adenocarcinomas. Results: no specific EGFR gene mutations were detected, while EGFR positive staining was detected in 6% of the cases. Conclusion: Our findings indicate that in gastric adenocarcinoma, specific EGFR gene mutations are very rare or absent and the rate of EGFR protein expression is low.",

keywords = "EGFR mutation, Epidermal growth factor receptor (EGFR), Gastric cancer, Immunohistochemistry",

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T2 - Mutational and protein expression analysis in gastric cancer

AU - Mammano, Enzo

AU - Belluco, Claudio

AU - Sciro, Manuela

AU - Mencarelli, Roberto

AU - Agostini, Marco

AU - Michelotto, Mauro

AU - Marchet, Alberto

AU - Nitti, Donato

PY - 2006/9/1

Y1 - 2006/9/1

N2 - Background: Since specific epidermal growth factor receptor (EGFR) somatic mutations have been demonstrated to influence the response to anti-EGFR therapy in non-small cell lung cancer, EGFR gene mutational analysis of different types of neoplasm is under investigation. Patients and Methods: EGFR protein expression and gene mutations in exons 18, 19 and 21 were investigated in 49 gastric adenocarcinomas. Results: no specific EGFR gene mutations were detected, while EGFR positive staining was detected in 6% of the cases. Conclusion: Our findings indicate that in gastric adenocarcinoma, specific EGFR gene mutations are very rare or absent and the rate of EGFR protein expression is low.

AB - Background: Since specific epidermal growth factor receptor (EGFR) somatic mutations have been demonstrated to influence the response to anti-EGFR therapy in non-small cell lung cancer, EGFR gene mutational analysis of different types of neoplasm is under investigation. Patients and Methods: EGFR protein expression and gene mutations in exons 18, 19 and 21 were investigated in 49 gastric adenocarcinomas. Results: no specific EGFR gene mutations were detected, while EGFR positive staining was detected in 6% of the cases. Conclusion: Our findings indicate that in gastric adenocarcinoma, specific EGFR gene mutations are very rare or absent and the rate of EGFR protein expression is low.

KW - EGFR mutation

KW - Epidermal growth factor receptor (EGFR)

KW - Gastric cancer

KW - Immunohistochemistry

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