Epidermal growth factor receptor derived peptide vaccination to prevent lung adenocarcinoma formation: An in vivo study in a murine model of EGFR mutant lung cancer

Johnathan D. Ebben, Ronald A. Lubet, Ekram Gad, Mary L. Disis, Ming You

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The ability to prevent disease is the holy grail of medicine. For decades, efforts have been made to extend the successes seen with vaccination against infectious diseases to cancer. In some instances, preventive vaccination against viruses (prototypically HPV) has successfully prevented tumorigenesis and will make a major impact on public health in the decades to come. However, the majority of cancers that arise are a result of genetic mutation within the host, or non-viral environmental exposures. We present compelling evidence that vaccination against an overexpressed self-tumor oncoprotein has the potential to prevent tumor development. Vaccination against the Epidermal Growth Factor Receptor (EGFR) using a multipeptide vaccine in a preventive setting decreased EGFR-driven lung carcinogenesis by 76.4% in a mouse model of EGFR-driven lung cancer. We also demonstrate that anti-EGFR vaccination primes the development of a robust immune response in vivo. This study provides proof of concept for the first time that targeting tumor drivers in a preventive setting in lung cancer using peptide vaccination can inhibit tumorigenesis and may provide useful clinical insights into the development of strategies to vaccinate against EGFR in populations where EGFR-mutant disease is highly prevalent.

Original languageEnglish (US)
Pages (from-to)1517-1525
Number of pages9
JournalMolecular Carcinogenesis
Volume55
Issue number11
DOIs
StatePublished - Nov 1 2016

Keywords

  • cancer prevention
  • lung cancer
  • peptide vaccine

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research

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