Epidemiology of Acute Otitis Media Caused by Streptococcus pneumoniae Before and After Licensure of the 7-Valent Pneumococcal Protein Conjugate Vaccine

M. Catherine McEllistrem, Jennifer Adams, Edward O. Mason, Ellen R. Wald

Research output: Contribution to journalArticle

84 Scopus citations

Abstract

We studied, by pulsed-field gel electrophoresis, multilocus sequence typing and penicillin-binding protein 2b amplicon-restriction profiles, pneumococcal isolates recovered from children with acute otitis media during 1 January-31 December 1999 and 2001. The proportion of nonvaccine serogroups increased from 14.8% (13/ 88) to 36.5% (23/63) from 1999 to 2001 (P < .01). Among children who received at least 2 doses of the pneumococcal 7-valent protein conjugate (PNC7) vaccine, 46.7% (7/15) of the isolates had nonvaccine serogroups, compared with 20.8% (26/125) of the isolates from children who did not receive the PNC7 vaccine (P = .05). Overall, the serogroups involved in capsular switching were 6-19-NT, 6-14-35, 15-19, and the 19-Spanish 23F clone. In 1999 and 2001, 30.8% (4/13) and 26.1% (6/23) of the nonvaccine serogroups were implicated in capsular switching, respectively. Continued surveillance will be of great importance as the distribution of the PNC7 vaccine increases.

Original languageEnglish (US)
Pages (from-to)1679-1684
Number of pages6
JournalJournal of Infectious Diseases
Volume188
Issue number11
DOIs
StatePublished - Dec 1 2003

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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