TY - JOUR
T1 - Epidemiology of Acute Otitis Media Caused by Streptococcus pneumoniae Before and After Licensure of the 7-Valent Pneumococcal Protein Conjugate Vaccine
AU - McEllistrem, M. Catherine
AU - Adams, Jennifer
AU - Mason, Edward O.
AU - Wald, Ellen R.
N1 - Funding Information:
Received 11 March 2003; accepted 30 May 2003; electronically published 10 November 2003. Presented in part: 40th annual meeting of the Infectious Diseases Society of America, Chicago, 24–27 October 2002 (abstract 733). Financial support: National Institutes of Health (grant K23-AI01788-01 to M.C.M.); Bristol Myers Squibb (to M.C.M. and E.R.W.). Reprints or correspondence: Dr. M. Catherine McEllistrem, Div. of Infectious Diseases, Ste. 3A, Falk Medical Bldg., 3601 Fifth Ave., University of Pittsburgh, Pittsburgh, PA 15213-2582.
PY - 2003/12/1
Y1 - 2003/12/1
N2 - We studied, by pulsed-field gel electrophoresis, multilocus sequence typing and penicillin-binding protein 2b amplicon-restriction profiles, pneumococcal isolates recovered from children with acute otitis media during 1 January-31 December 1999 and 2001. The proportion of nonvaccine serogroups increased from 14.8% (13/ 88) to 36.5% (23/63) from 1999 to 2001 (P < .01). Among children who received at least 2 doses of the pneumococcal 7-valent protein conjugate (PNC7) vaccine, 46.7% (7/15) of the isolates had nonvaccine serogroups, compared with 20.8% (26/125) of the isolates from children who did not receive the PNC7 vaccine (P = .05). Overall, the serogroups involved in capsular switching were 6-19-NT, 6-14-35, 15-19, and the 19-Spanish 23F clone. In 1999 and 2001, 30.8% (4/13) and 26.1% (6/23) of the nonvaccine serogroups were implicated in capsular switching, respectively. Continued surveillance will be of great importance as the distribution of the PNC7 vaccine increases.
AB - We studied, by pulsed-field gel electrophoresis, multilocus sequence typing and penicillin-binding protein 2b amplicon-restriction profiles, pneumococcal isolates recovered from children with acute otitis media during 1 January-31 December 1999 and 2001. The proportion of nonvaccine serogroups increased from 14.8% (13/ 88) to 36.5% (23/63) from 1999 to 2001 (P < .01). Among children who received at least 2 doses of the pneumococcal 7-valent protein conjugate (PNC7) vaccine, 46.7% (7/15) of the isolates had nonvaccine serogroups, compared with 20.8% (26/125) of the isolates from children who did not receive the PNC7 vaccine (P = .05). Overall, the serogroups involved in capsular switching were 6-19-NT, 6-14-35, 15-19, and the 19-Spanish 23F clone. In 1999 and 2001, 30.8% (4/13) and 26.1% (6/23) of the nonvaccine serogroups were implicated in capsular switching, respectively. Continued surveillance will be of great importance as the distribution of the PNC7 vaccine increases.
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U2 - 10.1086/379665
DO - 10.1086/379665
M3 - Article
C2 - 14639539
AN - SCOPUS:0346887083
VL - 188
SP - 1679
EP - 1684
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 11
ER -