Enzymatic conversion of magnetic nanoparticles to a non-magnetic precipitate: A new approach to magnetic sensing

Arati G. Kolhatkar; Andrew C. Jamison; Ivan Nekrashevich; Katerina Kourentzi; Dmitri Litvinov; Audrius Brazdeikis; Richard C. Willson; T. Randall Lee

doi:10.1039/c6an00709k

Enzymatic conversion of magnetic nanoparticles to a non-magnetic precipitate: A new approach to magnetic sensing

Arati G. Kolhatkar, Andrew C. Jamison, Ivan Nekrashevich, Katerina Kourentzi, Dmitri Litvinov, Audrius Brazdeikis, Richard C. Willson, T. Randall Lee

Research output: Contribution to journal › Article

3 Scopus citations

Abstract

Magnetic sensing utilizes the detection of biomolecule-conjugated magnetic nanoparticles (MNPs). Our new strategy offers a novel approach to magnetic sensing where in situ conversion produces a "loss of signal" in the sensing device. This report demonstrates the enzymatic conversion of Fe₃O₄ MNPs to a non-magnetic precipitate via reduction by l-ascorbic acid generated by the action of alkaline phosphatase.

Original language	English (US)
Pages (from-to)	5246-5251
Number of pages	6
Journal	Analyst
Volume	141
Issue number	18
DOIs	https://doi.org/10.1039/c6an00709k
State	Published - Sep 21 2016

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Environmental Chemistry
Spectroscopy
Electrochemistry

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10.1039/c6an00709k

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Enzymatic conversion of magnetic nanoparticles to a non-magnetic precipitate : A new approach to magnetic sensing. / Kolhatkar, Arati G.; Jamison, Andrew C.; Nekrashevich, Ivan; Kourentzi, Katerina; Litvinov, Dmitri; Brazdeikis, Audrius; Willson, Richard C.; Lee, T. Randall.

In: Analyst, Vol. 141, No. 18, 21.09.2016, p. 5246-5251.

Research output: Contribution to journal › Article

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