Enzymatic conversion of magnetic nanoparticles to a non-magnetic precipitate: A new approach to magnetic sensing

Arati G. Kolhatkar, Andrew C. Jamison, Ivan Nekrashevich, Katerina Kourentzi, Dmitri Litvinov, Audrius Brazdeikis, Richard C. Willson, T. Randall Lee

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Magnetic sensing utilizes the detection of biomolecule-conjugated magnetic nanoparticles (MNPs). Our new strategy offers a novel approach to magnetic sensing where in situ conversion produces a "loss of signal" in the sensing device. This report demonstrates the enzymatic conversion of Fe3O4 MNPs to a non-magnetic precipitate via reduction by l-ascorbic acid generated by the action of alkaline phosphatase.

Original languageEnglish (US)
Pages (from-to)5246-5251
Number of pages6
JournalAnalyst
Volume141
Issue number18
DOIs
StatePublished - Sep 21 2016

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy
  • Electrochemistry

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