Environmental Pollution and Cardiovascular Disease: Part 1 of 2: Air Pollution

Usman Sagheer, Sadeer Al-Kindi, Shady Abohashem, Colin T. Phillips, Jamal S. Rana, Aruni Bhatnagar, Martha Gulati, Sanjay Rajagopalan, Dinesh K. Kalra

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Over the past 50 years, there has been a substantial decline in the incidence of CVD and related mortality in high-income countries, largely due to the mitigation of modifiable risk factors such as smoking, hypertension, and diabetes. However, a significant burden of CVD remains in low- to middle-income countries, despite their lower prevalence of traditional risk factors; other environmental factors, particularly pollution, play a significant role in this attributable risk. Mounting evidence underscores a strong association between pollution and adverse health effects, including CVD. This article is part 1 of a two-part state-of-the-art review and discusses air pollution and its adverse effects on CVD, highlighting pathophysiological mechanisms and methods to reduce air pollution and exposure to these pollutants.

Original languageEnglish (US)
Article number100805
JournalJACC: Advances
Issue number2
StatePublished - Feb 2024


  • air pollution
  • global burden of disease
  • particulate matter

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Dentistry (miscellaneous)


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