Environmental levels and toxicological potencies of a novel mixed halogenated carbazole

Miren Pena-Abaurrea; Matthew Robson; Sri Chaudhuri; Nicole Riddell; Robert McCrindle; Brock Chittim; Robert Parette; Un Ho Jin; Stephen Safe; David Poirier; Ralph Ruffolo; Richard Dyer; Rachael Fletcher; Paul A. Helm; Eric J. Reiner

doi:10.1016/j.emcon.2016.07.002

Environmental levels and toxicological potencies of a novel mixed halogenated carbazole

Miren Pena-Abaurrea, Matthew Robson, Sri Chaudhuri, Nicole Riddell, Robert McCrindle, Brock Chittim, Robert Parette, Un Ho Jin, Stephen Safe, David Poirier, Ralph Ruffolo, Richard Dyer, Rachael Fletcher, Paul A. Helm, Eric J. Reiner

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The present work involves an extensive analytical and toxicological description of a recently identified mixed halogenated carbazole found in sediment samples, 1,8-dibromo-3,6-dichloro-9H-carbazole (BCCZ). Concentrations and the relative effect potency (REP) were calculated for the target BCCZ in a set of stream sediments collected in 2008 in Ontario, Canada. The levels calculated for BCCZ as compared to those previously assessed for legacy persistent organic pollutants (POPs) in the same samples revealed a significant contribution of BCCZ to the total organic chemical contamination (<1%–95%; average 37%). The corresponding dioxin toxic equivalencies (TEQs) of BCCZ in the sediment extracts were estimated from experimental REP data. The experimental data presented supports the classification of this emerging halogenated chemical as a contaminant of emerging environmental concern. Although potential emission sources could not be identified, this study highlights the importance of on-going research for complete characterization of halogenated carbazoles and related compounds.

Original language	English (US)
Pages (from-to)	166-172
Number of pages	7
Journal	Emerging Contaminants
Volume	2
Issue number	3
DOIs	https://doi.org/10.1016/j.emcon.2016.07.002
State	Published - Sep 2016

Keywords

Dioxin-like
GC×GC
Halogenated carbazoles
Levels
REP
Regulation
Risk assessment
TEQ

ASJC Scopus subject areas

Toxicology
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

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10.1016/j.emcon.2016.07.002

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Pena-Abaurrea, M., Robson, M., Chaudhuri, S., Riddell, N., McCrindle, R., Chittim, B., Parette, R., Jin, U. H., Safe, S., Poirier, D., Ruffolo, R., Dyer, R., Fletcher, R., Helm, P. A., & Reiner, E. J. (2016). Environmental levels and toxicological potencies of a novel mixed halogenated carbazole. Emerging Contaminants, 2(3), 166-172. https://doi.org/10.1016/j.emcon.2016.07.002

Pena-Abaurrea, M, Robson, M, Chaudhuri, S, Riddell, N, McCrindle, R, Chittim, B, Parette, R, Jin, UH, Safe, S, Poirier, D, Ruffolo, R, Dyer, R, Fletcher, R, Helm, PA & Reiner, EJ 2016, 'Environmental levels and toxicological potencies of a novel mixed halogenated carbazole', Emerging Contaminants, vol. 2, no. 3, pp. 166-172. https://doi.org/10.1016/j.emcon.2016.07.002

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abstract = "The present work involves an extensive analytical and toxicological description of a recently identified mixed halogenated carbazole found in sediment samples, 1,8-dibromo-3,6-dichloro-9H-carbazole (BCCZ). Concentrations and the relative effect potency (REP) were calculated for the target BCCZ in a set of stream sediments collected in 2008 in Ontario, Canada. The levels calculated for BCCZ as compared to those previously assessed for legacy persistent organic pollutants (POPs) in the same samples revealed a significant contribution of BCCZ to the total organic chemical contamination (<1%–95%; average 37%). The corresponding dioxin toxic equivalencies (TEQs) of BCCZ in the sediment extracts were estimated from experimental REP data. The experimental data presented supports the classification of this emerging halogenated chemical as a contaminant of emerging environmental concern. Although potential emission sources could not be identified, this study highlights the importance of on-going research for complete characterization of halogenated carbazoles and related compounds.",

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author = "Miren Pena-Abaurrea and Matthew Robson and Sri Chaudhuri and Nicole Riddell and Robert McCrindle and Brock Chittim and Robert Parette and Jin, {Un Ho} and Stephen Safe and David Poirier and Ralph Ruffolo and Richard Dyer and Rachael Fletcher and Helm, {Paul A.} and Reiner, {Eric J.}",

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AU - Chittim, Brock

AU - Parette, Robert

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AU - Safe, Stephen

AU - Poirier, David

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AU - Dyer, Richard

AU - Fletcher, Rachael

AU - Helm, Paul A.

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Environmental levels and toxicological potencies of a novel mixed halogenated carbazole

Abstract

Keywords

ASJC Scopus subject areas

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