Environmental factors responsible for variability of hepatic vein flow: A doppler assessment in healthy twins

Research output: Contribution to journalArticle

Adam D. Tarnoki, David L. Tarnoki, Levente Littvay, Zsolt Garami, Andrea Agnes Molnar, Viktor Berczi, Kinga Karlinger, Gyorgy Baffy

Doppler interrogation studies of the liver blood flow indicate altered hepatic vein waveforms in association with impaired hepatocellular function. However, little is known about the mechanisms responsible for variations of these parameters in the absence of disease. We aimed to investigate the contribution of heritable and environmental factors to the physiological variability of hepatic vein flow in a twin cohort. Two hundred twenty-eight healthy adult Hungarian twins (69 monozygotic, 45 same-sex dizygotic pairs) underwent Doppler sonography of the hepatic vein. Age- and sex-adjusted heritability of the highest velocity (amplitude of S wave) of hepatic vein flow was negligible. Shared environment contributed to 33% (95% CI, 16%-51%), and unshared environment was responsible for the largest portion (67%; 95% CI, 49%-84%) of the variance. Duration of sports activities was significantly (P <0.05) related to the magnitude of hepatic vein flow, while other risk factors and lifestyle characteristics had no significant influence. The data suggest that genetic factors have little impact on the parameters of hepatic venous blood flow. The variability observed in healthy twins by the Doppler interrogation can be explained by the effect of unshared environmental components primarily related to regular physical activity. These findings underscore the importance of unique environments in physiological variations of hepatic venous blood flow.

Original languageEnglish (US)
Pages (from-to)33-38
Number of pages6
JournalChinese Journal of Physiology
Volume59
Issue number1
DOIs
StatePublished - 2016

PMID: 26875560

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Environmental factors responsible for variability of hepatic vein flow : A doppler assessment in healthy twins. / Tarnoki, Adam D.; Tarnoki, David L.; Littvay, Levente; Garami, Zsolt; Molnar, Andrea Agnes; Berczi, Viktor; Karlinger, Kinga; Baffy, Gyorgy.

In: Chinese Journal of Physiology, Vol. 59, No. 1, 2016, p. 33-38.

Research output: Contribution to journalArticle

Harvard

Tarnoki, AD, Tarnoki, DL, Littvay, L, Garami, Z, Molnar, AA, Berczi, V, Karlinger, K & Baffy, G 2016, 'Environmental factors responsible for variability of hepatic vein flow: A doppler assessment in healthy twins' Chinese Journal of Physiology, vol. 59, no. 1, pp. 33-38. https://doi.org/10.4077/CJP.2016.BAE360

APA

Tarnoki, A. D., Tarnoki, D. L., Littvay, L., Garami, Z., Molnar, A. A., Berczi, V., ... Baffy, G. (2016). Environmental factors responsible for variability of hepatic vein flow: A doppler assessment in healthy twins. Chinese Journal of Physiology, 59(1), 33-38. https://doi.org/10.4077/CJP.2016.BAE360

Vancouver

Tarnoki AD, Tarnoki DL, Littvay L, Garami Z, Molnar AA, Berczi V et al. Environmental factors responsible for variability of hepatic vein flow: A doppler assessment in healthy twins. Chinese Journal of Physiology. 2016;59(1):33-38. https://doi.org/10.4077/CJP.2016.BAE360

Author

Tarnoki, Adam D. ; Tarnoki, David L. ; Littvay, Levente ; Garami, Zsolt ; Molnar, Andrea Agnes ; Berczi, Viktor ; Karlinger, Kinga ; Baffy, Gyorgy. / Environmental factors responsible for variability of hepatic vein flow : A doppler assessment in healthy twins. In: Chinese Journal of Physiology. 2016 ; Vol. 59, No. 1. pp. 33-38.

BibTeX

@article{eb84b9705c3b466c956b8989308d2117,
title = "Environmental factors responsible for variability of hepatic vein flow: A doppler assessment in healthy twins",
abstract = "Doppler interrogation studies of the liver blood flow indicate altered hepatic vein waveforms in association with impaired hepatocellular function. However, little is known about the mechanisms responsible for variations of these parameters in the absence of disease. We aimed to investigate the contribution of heritable and environmental factors to the physiological variability of hepatic vein flow in a twin cohort. Two hundred twenty-eight healthy adult Hungarian twins (69 monozygotic, 45 same-sex dizygotic pairs) underwent Doppler sonography of the hepatic vein. Age- and sex-adjusted heritability of the highest velocity (amplitude of S wave) of hepatic vein flow was negligible. Shared environment contributed to 33{\%} (95{\%} CI, 16{\%}-51{\%}), and unshared environment was responsible for the largest portion (67{\%}; 95{\%} CI, 49{\%}-84{\%}) of the variance. Duration of sports activities was significantly (P <0.05) related to the magnitude of hepatic vein flow, while other risk factors and lifestyle characteristics had no significant influence. The data suggest that genetic factors have little impact on the parameters of hepatic venous blood flow. The variability observed in healthy twins by the Doppler interrogation can be explained by the effect of unshared environmental components primarily related to regular physical activity. These findings underscore the importance of unique environments in physiological variations of hepatic venous blood flow.",
keywords = "Blood flow, Hepatocellular function, Liver, Physical activity, Velocity",
author = "Tarnoki, {Adam D.} and Tarnoki, {David L.} and Levente Littvay and Zsolt Garami and Molnar, {Andrea Agnes} and Viktor Berczi and Kinga Karlinger and Gyorgy Baffy",
year = "2016",
doi = "10.4077/CJP.2016.BAE360",
language = "English (US)",
volume = "59",
pages = "33--38",
journal = "Chinese Journal of Physiology",
issn = "0304-4920",
publisher = "Chinese Physiological Society",
number = "1",

}

RIS

TY - JOUR

T1 - Environmental factors responsible for variability of hepatic vein flow

T2 - Chinese Journal of Physiology

AU - Tarnoki, Adam D.

AU - Tarnoki, David L.

AU - Littvay, Levente

AU - Garami, Zsolt

AU - Molnar, Andrea Agnes

AU - Berczi, Viktor

AU - Karlinger, Kinga

AU - Baffy, Gyorgy

PY - 2016

Y1 - 2016

N2 - Doppler interrogation studies of the liver blood flow indicate altered hepatic vein waveforms in association with impaired hepatocellular function. However, little is known about the mechanisms responsible for variations of these parameters in the absence of disease. We aimed to investigate the contribution of heritable and environmental factors to the physiological variability of hepatic vein flow in a twin cohort. Two hundred twenty-eight healthy adult Hungarian twins (69 monozygotic, 45 same-sex dizygotic pairs) underwent Doppler sonography of the hepatic vein. Age- and sex-adjusted heritability of the highest velocity (amplitude of S wave) of hepatic vein flow was negligible. Shared environment contributed to 33% (95% CI, 16%-51%), and unshared environment was responsible for the largest portion (67%; 95% CI, 49%-84%) of the variance. Duration of sports activities was significantly (P <0.05) related to the magnitude of hepatic vein flow, while other risk factors and lifestyle characteristics had no significant influence. The data suggest that genetic factors have little impact on the parameters of hepatic venous blood flow. The variability observed in healthy twins by the Doppler interrogation can be explained by the effect of unshared environmental components primarily related to regular physical activity. These findings underscore the importance of unique environments in physiological variations of hepatic venous blood flow.

AB - Doppler interrogation studies of the liver blood flow indicate altered hepatic vein waveforms in association with impaired hepatocellular function. However, little is known about the mechanisms responsible for variations of these parameters in the absence of disease. We aimed to investigate the contribution of heritable and environmental factors to the physiological variability of hepatic vein flow in a twin cohort. Two hundred twenty-eight healthy adult Hungarian twins (69 monozygotic, 45 same-sex dizygotic pairs) underwent Doppler sonography of the hepatic vein. Age- and sex-adjusted heritability of the highest velocity (amplitude of S wave) of hepatic vein flow was negligible. Shared environment contributed to 33% (95% CI, 16%-51%), and unshared environment was responsible for the largest portion (67%; 95% CI, 49%-84%) of the variance. Duration of sports activities was significantly (P <0.05) related to the magnitude of hepatic vein flow, while other risk factors and lifestyle characteristics had no significant influence. The data suggest that genetic factors have little impact on the parameters of hepatic venous blood flow. The variability observed in healthy twins by the Doppler interrogation can be explained by the effect of unshared environmental components primarily related to regular physical activity. These findings underscore the importance of unique environments in physiological variations of hepatic venous blood flow.

KW - Blood flow

KW - Hepatocellular function

KW - Liver

KW - Physical activity

KW - Velocity

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U2 - 10.4077/CJP.2016.BAE360

DO - 10.4077/CJP.2016.BAE360

M3 - Article

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SP - 33

EP - 38

JO - Chinese Journal of Physiology

JF - Chinese Journal of Physiology

SN - 0304-4920

IS - 1

ER -

ID: 19906425