TY - JOUR
T1 - Environmental Exposome and Atrial Fibrillation
T2 - Emerging Evidence and Future Directions
AU - Wass, Sojin Youn
AU - Hahad, Omar
AU - Asad, Zain
AU - Li, Shuo
AU - Chung, Mina K.
AU - Benjamin, Emelia J.
AU - Nasir, Khurram
AU - Rajagopalan, Sanjay
AU - Al-Kindi, Sadeer G.
N1 - Publisher Copyright:
© 2024 Lippincott Williams and Wilkins. All rights reserved.
PY - 2024/4/12
Y1 - 2024/4/12
N2 - There has been increased awareness of the linkage between environmental exposures and cardiovascular health and disease. Atrial fibrillation is the most common sustained cardiac arrhythmia, affecting millions of people worldwide and contributing to substantial morbidity and mortality. Although numerous studies have explored the role of genetic and lifestyle factors in the development and progression of atrial fibrillation, the potential impact of environmental determinants on this prevalent condition has received comparatively less attention. This review aims to provide a comprehensive overview of the current evidence on environmental determinants of atrial fibrillation, encompassing factors such as air pollution, temperature, humidity, and other meteorologic conditions, noise pollution, greenspace, and the social environment. We discuss the existing evidence from epidemiological and mechanistic studies, critically evaluating the strengths and limitations of these investigations and the potential underlying biological mechanisms through which environmental exposures may affect atrial fibrillation risk. Furthermore, we address the potential implications of these findings for public health and clinical practice and identify knowledge gaps and future research directions in this emerging field.
AB - There has been increased awareness of the linkage between environmental exposures and cardiovascular health and disease. Atrial fibrillation is the most common sustained cardiac arrhythmia, affecting millions of people worldwide and contributing to substantial morbidity and mortality. Although numerous studies have explored the role of genetic and lifestyle factors in the development and progression of atrial fibrillation, the potential impact of environmental determinants on this prevalent condition has received comparatively less attention. This review aims to provide a comprehensive overview of the current evidence on environmental determinants of atrial fibrillation, encompassing factors such as air pollution, temperature, humidity, and other meteorologic conditions, noise pollution, greenspace, and the social environment. We discuss the existing evidence from epidemiological and mechanistic studies, critically evaluating the strengths and limitations of these investigations and the potential underlying biological mechanisms through which environmental exposures may affect atrial fibrillation risk. Furthermore, we address the potential implications of these findings for public health and clinical practice and identify knowledge gaps and future research directions in this emerging field.
KW - air pollution
KW - atrial fibrillation
KW - cardiovascular diseases
KW - environmental exposure
KW - exposome
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U2 - 10.1161/CIRCRESAHA.123.323477
DO - 10.1161/CIRCRESAHA.123.323477
M3 - Review article
C2 - 38603473
AN - SCOPUS:85190463926
SN - 0009-7330
VL - 134
SP - 1029
EP - 1045
JO - Circulation Research
JF - Circulation Research
IS - 8
ER -