TY - JOUR
T1 - Environmental contributions to the allergic asthma epidemic.
AU - Kheradmand, Farrah
AU - Rishi, Kirtee
AU - Corry, David
N1 - Copyright:
This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
PY - 2002/8
Y1 - 2002/8
N2 - Current data overwhelmingly document the existence of a worldwide asthma epidemic, although individual studies remain controversial. The epidemic is thought to involve primarily persons with allergic asthma, and many diverse theories, based on an immunopathologic understanding of disease, have recently emerged to explain this involvement. In the context of recent insights into the immune basis of experimental asthma, we discuss in this review the leading asthma epidemic theories, including a new theory based on inhaled environmental proteases. Although no single theory may yet be fully embraced, there exists substantial hope that a unifying mechanism for the epidemic will be revealed through additional research.
AB - Current data overwhelmingly document the existence of a worldwide asthma epidemic, although individual studies remain controversial. The epidemic is thought to involve primarily persons with allergic asthma, and many diverse theories, based on an immunopathologic understanding of disease, have recently emerged to explain this involvement. In the context of recent insights into the immune basis of experimental asthma, we discuss in this review the leading asthma epidemic theories, including a new theory based on inhaled environmental proteases. Although no single theory may yet be fully embraced, there exists substantial hope that a unifying mechanism for the epidemic will be revealed through additional research.
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U2 - 10.1289/ehp.02110s4553
DO - 10.1289/ehp.02110s4553
M3 - Review article
C2 - 12194885
AN - SCOPUS:0036675911
VL - 110 Suppl 4
SP - 553
EP - 556
JO - Environmental health perspectives
JF - Environmental health perspectives
SN - 0091-6765
ER -