Entropic trapping and escape of long DNA molecules at submicron size constriction

J. Han, S. W. Turner, H. G. Craighead

Research output: Contribution to journalArticle

353 Scopus citations

Abstract

We studied the passage of DNA molecules, driven by an electric field, through a microfabricated channel with 90 nm size constrictions. DNA molecules were entropically trapped at the constriction and escaped with a characteristic lifetime. Counterintuitively, longer DNA were found to escape entropic traps faster than shorter ones. DNA molecules overcome the entropic barrier by stretching their monomers into the constriction, which results in the fact that the energy barrier for DNA escape is independent of the chain length.

Original languageEnglish (US)
Pages (from-to)1688-1691
Number of pages4
JournalPhysical Review Letters
Volume83
Issue number8
DOIs
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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