Enterococcus faecium Clade Competition in the Presence of β-Lactam Antibiotics in a Mouse GI Tract Colonization Model

Kavindra V. Singh; Barbara Murray; Maria Camila Montealegre

doi:10.1128/aac.00903-22

Enterococcus faecium Clade Competition in the Presence of β-Lactam Antibiotics in a Mouse GI Tract Colonization Model

Kavindra V. Singh, Barbara Murray, Maria Camila Montealegre

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Previously, we showed that Enterococcus faecium clade B strains outcompeted health care-associated clade A1 strains in murine gastrointestinal colonization. Here, parenterally administered piperacillin-tazobactam and ceftriaxone significantly promoted colonization by clade A1 over clade B strains except that ceftriaxone, at the dose used, did not favor the least β-lactam-resistant A1 strain. The advantage that β-lactam administration gives to more highly ampicillin-resistant E. faecium over ampicillin-susceptible strains mirrors what occurs in hospitalized patients administered these antibiotics.

Original language	English (US)
Article number	https://doi.org/10.1128/aac.00903-22
Pages (from-to)	1 - 5
Number of pages	5
Journal	Antimicrobial Agents and Chemotherapy
Volume	66
Issue number	11
DOIs	https://doi.org/10.1128/aac.00903-22
State	Published - Oct 18 2022

Keywords

E. faecium
ampicillin resistant
ceftriaxone
mouse GI colonization
piperacillin-tazobactam
beta-Lactams/pharmacology
Gastrointestinal Tract
Monobactams
Anti-Bacterial Agents/pharmacology
Ceftriaxone/pharmacology
Enterococcus faecium
Animals
Ampicillin/pharmacology
Mice

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology

Divisions

Infectious Disease

Access to Document

10.1128/aac.00903-22

Cite this

Enterococcus faecium Clade Competition in the Presence of β-Lactam Antibiotics in a Mouse GI Tract Colonization Model. / Singh, Kavindra V.; Murray, Barbara; Montealegre, Maria Camila.
In: Antimicrobial Agents and Chemotherapy, Vol. 66, No. 11, https://doi.org/10.1128/aac.00903-22, 18.10.2022, p. 1 - 5.

Research output: Contribution to journal › Article › peer-review

@article{440b94153e694a2dacdb6dd9108dec5c,

title = "Enterococcus faecium Clade Competition in the Presence of β-Lactam Antibiotics in a Mouse GI Tract Colonization Model",

abstract = "Previously, we showed that Enterococcus faecium clade B strains outcompeted health care-associated clade A1 strains in murine gastrointestinal colonization. Here, parenterally administered piperacillin-tazobactam and ceftriaxone significantly promoted colonization by clade A1 over clade B strains except that ceftriaxone, at the dose used, did not favor the least β-lactam-resistant A1 strain. The advantage that β-lactam administration gives to more highly ampicillin-resistant E. faecium over ampicillin-susceptible strains mirrors what occurs in hospitalized patients administered these antibiotics.",

keywords = "E. faecium, ampicillin resistant, ceftriaxone, mouse GI colonization, piperacillin-tazobactam, beta-Lactams/pharmacology, Gastrointestinal Tract, Monobactams, Anti-Bacterial Agents/pharmacology, Ceftriaxone/pharmacology, Enterococcus faecium, Animals, Ampicillin/pharmacology, Mice",

author = "Singh, \{Kavindra V.\} and Barbara Murray and Montealegre, \{Maria Camila\}",

note = "Funding Information: This work was supported by the National Institutes of Health from the Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases (grant R21 AI103260-01 to B.E.M.). B.E.M. and K.V.S. were in part supported by R21AI133289-01A1 from NIAID. We thank Karen Jacques-Palaz for technical assistance. Publisher Copyright: {\textcopyright} 2022 American Society for Microbiology.",

year = "2022",

month = oct,

day = "18",

doi = "10.1128/aac.00903-22",

language = "English (US)",

volume = "66",

pages = "1 -- 5",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "11",

}

TY - JOUR

T1 - Enterococcus faecium Clade Competition in the Presence of β-Lactam Antibiotics in a Mouse GI Tract Colonization Model

AU - Singh, Kavindra V.

AU - Murray, Barbara

AU - Montealegre, Maria Camila

N1 - Funding Information: This work was supported by the National Institutes of Health from the Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases (grant R21 AI103260-01 to B.E.M.). B.E.M. and K.V.S. were in part supported by R21AI133289-01A1 from NIAID. We thank Karen Jacques-Palaz for technical assistance. Publisher Copyright: © 2022 American Society for Microbiology.

PY - 2022/10/18

Y1 - 2022/10/18

N2 - Previously, we showed that Enterococcus faecium clade B strains outcompeted health care-associated clade A1 strains in murine gastrointestinal colonization. Here, parenterally administered piperacillin-tazobactam and ceftriaxone significantly promoted colonization by clade A1 over clade B strains except that ceftriaxone, at the dose used, did not favor the least β-lactam-resistant A1 strain. The advantage that β-lactam administration gives to more highly ampicillin-resistant E. faecium over ampicillin-susceptible strains mirrors what occurs in hospitalized patients administered these antibiotics.

AB - Previously, we showed that Enterococcus faecium clade B strains outcompeted health care-associated clade A1 strains in murine gastrointestinal colonization. Here, parenterally administered piperacillin-tazobactam and ceftriaxone significantly promoted colonization by clade A1 over clade B strains except that ceftriaxone, at the dose used, did not favor the least β-lactam-resistant A1 strain. The advantage that β-lactam administration gives to more highly ampicillin-resistant E. faecium over ampicillin-susceptible strains mirrors what occurs in hospitalized patients administered these antibiotics.

KW - E. faecium

KW - ampicillin resistant

KW - ceftriaxone

KW - mouse GI colonization

KW - piperacillin-tazobactam

KW - beta-Lactams/pharmacology

KW - Gastrointestinal Tract

KW - Monobactams

KW - Anti-Bacterial Agents/pharmacology

KW - Ceftriaxone/pharmacology

KW - Enterococcus faecium

KW - Animals

KW - Ampicillin/pharmacology

KW - Mice

UR - https://www.scopus.com/pages/publications/85141938335

UR - https://www.scopus.com/inward/citedby.url?scp=85141938335&partnerID=8YFLogxK

U2 - 10.1128/aac.00903-22

DO - 10.1128/aac.00903-22

M3 - Article

C2 - 36255277

SN - 0066-4804

VL - 66

SP - 1

EP - 5

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 11

M1 - https://doi.org/10.1128/aac.00903-22

ER -

Enterococcus faecium Clade Competition in the Presence of β-Lactam Antibiotics in a Mouse GI Tract Colonization Model

Abstract

Keywords

ASJC Scopus subject areas

Divisions

Access to Document

Other files and links

Fingerprint

Cite this