Enterococcus faecalis mutations affecting virulence in the Caenorhabditis elegans model host

Arash Maadani, Kristina A. Fox, Elftherios Mylonakis, Danielle A. Garsin

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

Enterococcus faecalis transposon insertion mutants were screened for attenuated killing of the nematode model host Caenorhabditis elegans. The genes disrupted in the attenuated mutants encode a variety of factors including transcriptional regulators, transporters, and damage control and repair systems. Five of nine mutants tested were attenuated in a mouse peritonitis model.

Original languageEnglish (US)
Pages (from-to)2634-2637
Number of pages4
JournalInfection and Immunity
Volume75
Issue number5
DOIs
StatePublished - May 2007

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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