Entangling of Peptide Nanofibers Reduces the Invasiveness of SARS-CoV-2

Pei Pei Yang, Xin Wei Ye, Mei Qin Liu, Jin Xuan Yang, Xiao Li Feng, Yi Jing Li, Kuo Zhang, Hong Wen Liang, Yu Yi, Lei Wang, Yi Xuan Liu, Xing Lou Yang, Zheng Li Shi, Li Qiang Feng, Ling Chen, Yintong Xue, Qiang Pan-Hammarström, Hao Wang, Yuliang Zhao

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The viral spike (S) protein on the surface of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to angiotensin-converting enzyme 2 (ACE2) receptors on the host cells, facilitating its entry and infection. Here, functionalized nanofibers targeting the S protein with peptide sequences of IRQFFKK, WVHFYHK and NSGGSVH, which are screened from a high-throughput one-bead one-compound screening strategy, are designed and prepared. The flexible nanofibers support multiple binding sites and efficiently entangle SARS-CoV-2, forming a nanofibrous network that blocks the interaction between the S protein of SARS-CoV-2 and the ACE2 on host cells, and efficiently reduce the invasiveness of SARS-CoV-2. In summary, nanofibers entangling represents a smart nanomedicine for the prevention of SARS-CoV-2.

Original languageEnglish (US)
Article number2300673
JournalAdvanced Healthcare Materials
Volume12
Issue number24
DOIs
StatePublished - Sep 25 2023

Keywords

  • anti-virals
  • biomimetics
  • nanofibers
  • peptides
  • self-assembly

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

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