Abstract
The viral spike (S) protein on the surface of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to angiotensin-converting enzyme 2 (ACE2) receptors on the host cells, facilitating its entry and infection. Here, functionalized nanofibers targeting the S protein with peptide sequences of IRQFFKK, WVHFYHK and NSGGSVH, which are screened from a high-throughput one-bead one-compound screening strategy, are designed and prepared. The flexible nanofibers support multiple binding sites and efficiently entangle SARS-CoV-2, forming a nanofibrous network that blocks the interaction between the S protein of SARS-CoV-2 and the ACE2 on host cells, and efficiently reduce the invasiveness of SARS-CoV-2. In summary, nanofibers entangling represents a smart nanomedicine for the prevention of SARS-CoV-2.
Original language | English (US) |
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Article number | 2300673 |
Journal | Advanced Healthcare Materials |
Volume | 12 |
Issue number | 24 |
DOIs | |
State | Published - Sep 25 2023 |
Keywords
- anti-virals
- biomimetics
- nanofibers
- peptides
- self-assembly
ASJC Scopus subject areas
- Biomaterials
- Biomedical Engineering
- Pharmaceutical Science