TY - JOUR
T1 - Enhancing cancer immunotherapy through nanotechnology-mediated tumor infiltration and activation of immune cells
AU - Shen, Haifa
AU - Sun, Tong
AU - Hoang, Hanh H.
AU - Burchfield, Jana S.
AU - Hamilton, Gillian F.
AU - Mittendorf, Elizabeth A.
AU - Ferrari, Mauro
N1 - Funding Information:
The authors acknowledge funding support from the National Institutes of Health ( U54CA210181 and R01CA193880-01 ) and US Department of Defense ( W81XWH-12-1-0414 ). MF is the Ernest Cockrell Jr. Presidential Distinguished Chair at Houston Methodist Research Institute. EAM is a R. Lee Clark Fellow at the University of Texas MD Anderson Cancer Center, supported by the Jeanne F. Shelby Scholarship Fund. Matthew Landry (Houston Methodist Research Institute, Office of Strategic Research Initiatives) contributed to the figure schematic.
Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017/12
Y1 - 2017/12
N2 - Cancer immunotherapy has become arguably the most promising advancement in cancer research and therapy in recent years. The efficacy of cancer immunotherapy is critically dependent on specific physiological and physical processes – collectively referred to as transport barriers – including the activation of T cells by antigen presenting cells, T cells migration to and penetration into the tumor microenvironment, and movement of nutrients and other immune cells through the tumor microenvironment. Nanotechnology-based approaches have great potential to help overcome these transport barriers. In this review, we discuss the ways that nanotechnology is being leveraged to improve the efficacy and potency of various cancer immunotherapies.
AB - Cancer immunotherapy has become arguably the most promising advancement in cancer research and therapy in recent years. The efficacy of cancer immunotherapy is critically dependent on specific physiological and physical processes – collectively referred to as transport barriers – including the activation of T cells by antigen presenting cells, T cells migration to and penetration into the tumor microenvironment, and movement of nutrients and other immune cells through the tumor microenvironment. Nanotechnology-based approaches have great potential to help overcome these transport barriers. In this review, we discuss the ways that nanotechnology is being leveraged to improve the efficacy and potency of various cancer immunotherapies.
KW - Cancer immunotherapy
KW - Nanotechnology
KW - Tumor microenvironment
KW - Tumor-infiltrating lymphocytes
UR - http://www.scopus.com/inward/record.url?scp=85029764434&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85029764434&partnerID=8YFLogxK
U2 - 10.1016/j.smim.2017.09.002
DO - 10.1016/j.smim.2017.09.002
M3 - Review article
C2 - 28947107
AN - SCOPUS:85029764434
VL - 34
SP - 114
EP - 122
JO - Seminars in Immunology
JF - Seminars in Immunology
SN - 1044-5323
ER -