Enhancing cancer immunotherapy through nanotechnology-mediated tumor infiltration and activation of immune cells

Haifa Shen; Tong Sun; Hanh H. Hoang; Jana S. Burchfield; Gillian F. Hamilton; Elizabeth A. Mittendorf; Mauro Ferrari

doi:10.1016/j.smim.2017.09.002

Enhancing cancer immunotherapy through nanotechnology-mediated tumor infiltration and activation of immune cells

Haifa Shen, Tong Sun, Hanh H. Hoang, Jana S. Burchfield, Gillian F. Hamilton, Elizabeth A. Mittendorf, Mauro Ferrari

Research output: Contribution to journal › Review article

16 Scopus citations

Abstract

Cancer immunotherapy has become arguably the most promising advancement in cancer research and therapy in recent years. The efficacy of cancer immunotherapy is critically dependent on specific physiological and physical processes – collectively referred to as transport barriers – including the activation of T cells by antigen presenting cells, T cells migration to and penetration into the tumor microenvironment, and movement of nutrients and other immune cells through the tumor microenvironment. Nanotechnology-based approaches have great potential to help overcome these transport barriers. In this review, we discuss the ways that nanotechnology is being leveraged to improve the efficacy and potency of various cancer immunotherapies.

Original language	English (US)
Pages (from-to)	114-122
Number of pages	9
Journal	Seminars in Immunology
Volume	34
DOIs	https://doi.org/10.1016/j.smim.2017.09.002
State	Published - Dec 2017

Keywords

Cancer immunotherapy
Nanotechnology
Tumor microenvironment
Tumor-infiltrating lymphocytes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.smim.2017.09.002

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title = "Enhancing cancer immunotherapy through nanotechnology-mediated tumor infiltration and activation of immune cells",

abstract = "Cancer immunotherapy has become arguably the most promising advancement in cancer research and therapy in recent years. The efficacy of cancer immunotherapy is critically dependent on specific physiological and physical processes – collectively referred to as transport barriers – including the activation of T cells by antigen presenting cells, T cells migration to and penetration into the tumor microenvironment, and movement of nutrients and other immune cells through the tumor microenvironment. Nanotechnology-based approaches have great potential to help overcome these transport barriers. In this review, we discuss the ways that nanotechnology is being leveraged to improve the efficacy and potency of various cancer immunotherapies.",

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AU - Sun, Tong

AU - Hoang, Hanh H.

AU - Burchfield, Jana S.

AU - Hamilton, Gillian F.

AU - Mittendorf, Elizabeth A.

AU - Ferrari, Mauro

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AB - Cancer immunotherapy has become arguably the most promising advancement in cancer research and therapy in recent years. The efficacy of cancer immunotherapy is critically dependent on specific physiological and physical processes – collectively referred to as transport barriers – including the activation of T cells by antigen presenting cells, T cells migration to and penetration into the tumor microenvironment, and movement of nutrients and other immune cells through the tumor microenvironment. Nanotechnology-based approaches have great potential to help overcome these transport barriers. In this review, we discuss the ways that nanotechnology is being leveraged to improve the efficacy and potency of various cancer immunotherapies.

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KW - Tumor microenvironment

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