The oral absorption of biological macromolecules is one of the most challenging and extensively studied topics in drug delivery research. The main obstacles associated with oral administration and absorption of therapeutic macromolecules are the gastrointestinal (GI) membrane impermeability to the large hydrophilic molecules and their susceptibility to inactivation by GI enzymes. Various formulation approaches have been investigated to enhance GI delivery of biological macromolecules including permeability of GI membrane by use of surfactants, inhibition of enzymatic cleavage (reviewed in Chapter 5), enhancement of tight junction permeability, and use of carrier molecules and systems. This chapter will review tight junction modulators and various carriers used in oral drug delivery with a particular focus on the enhancing effects of surfactants on GI delivery.
|Original language||English (US)|
|Title of host publication||Enhancement in Drug Delivery|
|Number of pages||21|
|State||Published - Jan 1 2006|
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)