Enhancement of the sensitivity of surface plasmon resonance biosensor with colloidal gold labeling technique

J. H. Gu, H. Lu, Y. W. Chen, L. Y. Liu, P. Wang, J. M. Ma, Z. H. Lu

Research output: Contribution to journalConference article

26 Scopus citations

Abstract

In our experiment, colloidal gold was used to enhance the signal obtained from the surface-plasmon-resonance biosensor. Fab' fragments of human IgG molecules were immobilized on the gold surface and reacted with the sheep-anti-human IgG(SAH-IgG) molecules in solution. It was found that when the colloidal gold labeling technique was introduced the sensitivity of surface plasmon resonance instruments increased by a factor of about 300.

Original languageEnglish (US)
Pages (from-to)695-698
Number of pages4
JournalSupramolecular Science
Volume5
Issue number5-6
DOIs
StatePublished - 1998
EventProceedings of the 7th International Conference on Molecular Electronics and Biocomputing - Nanjing, China
Duration: Nov 10 1997Nov 12 1997

ASJC Scopus subject areas

  • Engineering(all)

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