Enhancement of [123I]β-CIT binding in the striatum with clomipramine: Is there a serotonin-dopamine interaction?

Masahiro Fujita, Keizo Takatoku, Yoshinori Matoba, Masaru Nishiura, Kaoru Kobayashi, Osamu Inoue, Tsunehiko Nishimura

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Many reports support the concept of serotonergic-dopaminergic interaction in the brain. However, at present, there are few methods to study this relationship in vivo. The purpose of this study was to investigate the effect of serotonin (5-HT) uptake inhibitor, clomipramine, on a dopamine (DA) transporter ligand, [123I]β-CIT (RTI-55), in rat brain. Dose-dependent changes in [123I]β-CIT specific binding induced by clomipramine were studied in the striatum (rich in DA transporter) and the hypothalamus (rich in 5-HT transporter). The changes in the time-activity curves of [123I]β-CIT specific binding after clomipramine injection were also examined in these two regions. Using the cerebellum as the reference region, κ3 and κ4 values with and without clomipramine administration were estimated by a two-compartment kinetic analysis. Clomipramine inhibited [123I]β-CIT specific binding in the hypothalamus, but enhanced its specific binding in the striatum in a dose-dependent manner. Kinetic analysis showed that κ3 in the striatum was increased by 55%. In conclusion, enhancement of [123I]β-CIT binding in the striatum after clomipramine administration indicated the possibility of 5-HT-DA interaction.

Original languageEnglish (US)
Pages (from-to)403-408
Number of pages6
JournalEuropean Journal of Nuclear Medicine
Volume24
Issue number4
DOIs
StatePublished - 1997

Keywords

  • 3β-(4-iodophenyl)tropan-2β-carboxylic acid
  • Dopamine
  • Serotonin
  • Single-photon emission tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Enhancement of [<sup>123</sup>I]β-CIT binding in the striatum with clomipramine: Is there a serotonin-dopamine interaction?'. Together they form a unique fingerprint.

Cite this