Enhanced stereotypic behavior by chronic treatment with bromocriptine accompanies increase of D-1 receptor binding

Le Wei-Dong, Zhou Xiao-Da, Jin Guo-Zhang

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Different effects of chronic treatment with bromocriptine (BRO) on D-1 and D-2 receptors in the rat were studied through behavioral observation and DA receptor binding assays. Chronic BRO led to enhancement of stereotypy to apomorphine (APO), at the same time it increased the density of D-1 receptor binding by 43 % and decreased that of D-2 receptor binding by 21 %. Our data suggest that BRO has different effects on D-1 and D-2 receptors and the behavioral hypersensitivity caused by BRO may be relevant to the proliferation of D-1 receptor.

Original languageEnglish (US)
Pages (from-to)1841-1845
Number of pages5
JournalLife sciences
Volume42
Issue number19
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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