Enhanced stereotypic behavior by chronic treatment with bromocriptine accompanies increase of D-1 receptor binding

Le Wei-Dong; Zhou Xiao-Da; Jin Guo-Zhang

doi:10.1016/0024-3205(88)90022-7

Enhanced stereotypic behavior by chronic treatment with bromocriptine accompanies increase of D-1 receptor binding

Le Wei-Dong, Zhou Xiao-Da, Jin Guo-Zhang

Houston Methodist

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Different effects of chronic treatment with bromocriptine (BRO) on D-1 and D-2 receptors in the rat were studied through behavioral observation and DA receptor binding assays. Chronic BRO led to enhancement of stereotypy to apomorphine (APO), at the same time it increased the density of D-1 receptor binding by 43 % and decreased that of D-2 receptor binding by 21 %. Our data suggest that BRO has different effects on D-1 and D-2 receptors and the behavioral hypersensitivity caused by BRO may be relevant to the proliferation of D-1 receptor.

Original language	English (US)
Pages (from-to)	1841-1845
Number of pages	5
Journal	Life sciences
Volume	42
Issue number	19
DOIs	https://doi.org/10.1016/0024-3205(88)90022-7
State	Published - 1988

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(88)90022-7

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title = "Enhanced stereotypic behavior by chronic treatment with bromocriptine accompanies increase of D-1 receptor binding",

abstract = "Different effects of chronic treatment with bromocriptine (BRO) on D-1 and D-2 receptors in the rat were studied through behavioral observation and DA receptor binding assays. Chronic BRO led to enhancement of stereotypy to apomorphine (APO), at the same time it increased the density of D-1 receptor binding by 43 % and decreased that of D-2 receptor binding by 21 %. Our data suggest that BRO has different effects on D-1 and D-2 receptors and the behavioral hypersensitivity caused by BRO may be relevant to the proliferation of D-1 receptor.",

author = "Le Wei-Dong and Zhou Xiao-Da and Jin Guo-Zhang",

year = "1988",

doi = "10.1016/0024-3205(88)90022-7",

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T1 - Enhanced stereotypic behavior by chronic treatment with bromocriptine accompanies increase of D-1 receptor binding

AU - Wei-Dong, Le

AU - Xiao-Da, Zhou

AU - Guo-Zhang, Jin

PY - 1988

Y1 - 1988

N2 - Different effects of chronic treatment with bromocriptine (BRO) on D-1 and D-2 receptors in the rat were studied through behavioral observation and DA receptor binding assays. Chronic BRO led to enhancement of stereotypy to apomorphine (APO), at the same time it increased the density of D-1 receptor binding by 43 % and decreased that of D-2 receptor binding by 21 %. Our data suggest that BRO has different effects on D-1 and D-2 receptors and the behavioral hypersensitivity caused by BRO may be relevant to the proliferation of D-1 receptor.

AB - Different effects of chronic treatment with bromocriptine (BRO) on D-1 and D-2 receptors in the rat were studied through behavioral observation and DA receptor binding assays. Chronic BRO led to enhancement of stereotypy to apomorphine (APO), at the same time it increased the density of D-1 receptor binding by 43 % and decreased that of D-2 receptor binding by 21 %. Our data suggest that BRO has different effects on D-1 and D-2 receptors and the behavioral hypersensitivity caused by BRO may be relevant to the proliferation of D-1 receptor.

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JO - Life sciences

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Enhanced stereotypic behavior by chronic treatment with bromocriptine accompanies increase of D-1 receptor binding

Abstract

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