Enhanced Petri Net: Elucidating the pathway-level mechanism of targeted-therapy drugs

Guangxu Jin; Stephen T.C. Wong

doi:10.1515/itit-2013-1019

Enhanced Petri Net: Elucidating the pathway-level mechanism of targeted-therapy drugs

Research output: Contribution to journal › Article › peer-review

Abstract

Characterizing the dynamics of cellular signaling pathways with external simuli or drug treatment is critical for the understanding of mechanisms of cellular behavors. Petri Net, as a non-parametric approach, has been widely used for studying dynamics of a large scale of signaling network only based on the connections (interactions) within this network. In this article, we will describe an extension of the Petri net methods, called Enhanced Petri Net (EPN), specifcally designed for analyzing and modeling the dynamics of signaling pathways in order to predict the unknown signaling mechanisms of targeted-therapy drugs.

Original language	English (US)
Pages (from-to)	67-75
Number of pages	9
Journal	IT - Information Technology
Volume	56
Issue number	2
DOIs	https://doi.org/10.1515/itit-2013-1019
State	Published - Apr 28 2014

Keywords

ACM CCS→Computing methodologies→Modeling and simulation
ACM CCS→Mathematics of computing→Discrete mathematics

ASJC Scopus subject areas

General Computer Science

Divisions

Medical Oncology

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10.1515/itit-2013-1019

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title = "Enhanced Petri Net: Elucidating the pathway-level mechanism of targeted-therapy drugs",

abstract = "Characterizing the dynamics of cellular signaling pathways with external simuli or drug treatment is critical for the understanding of mechanisms of cellular behavors. Petri Net, as a non-parametric approach, has been widely used for studying dynamics of a large scale of signaling network only based on the connections (interactions) within this network. In this article, we will describe an extension of the Petri net methods, called Enhanced Petri Net (EPN), specifcally designed for analyzing and modeling the dynamics of signaling pathways in order to predict the unknown signaling mechanisms of targeted-therapy drugs.",

keywords = "ACM CCS→Computing methodologies→Modeling and simulation, ACM CCS→Mathematics of computing→Discrete mathematics",

author = "Guangxu Jin and Wong, \{Stephen T.C.\}",

note = "Publisher Copyright: {\textcopyright} 2014 Walter de Gruyter Berlin/Boston 2014.",

year = "2014",

month = apr,

day = "28",

doi = "10.1515/itit-2013-1019",

language = "English (US)",

volume = "56",

pages = "67--75",

journal = "IT - Information Technology",

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publisher = "De Gruyter Oldenbourg",

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T1 - Enhanced Petri Net

T2 - Elucidating the pathway-level mechanism of targeted-therapy drugs

AU - Jin, Guangxu

AU - Wong, Stephen T.C.

PY - 2014/4/28

Y1 - 2014/4/28

N2 - Characterizing the dynamics of cellular signaling pathways with external simuli or drug treatment is critical for the understanding of mechanisms of cellular behavors. Petri Net, as a non-parametric approach, has been widely used for studying dynamics of a large scale of signaling network only based on the connections (interactions) within this network. In this article, we will describe an extension of the Petri net methods, called Enhanced Petri Net (EPN), specifcally designed for analyzing and modeling the dynamics of signaling pathways in order to predict the unknown signaling mechanisms of targeted-therapy drugs.

AB - Characterizing the dynamics of cellular signaling pathways with external simuli or drug treatment is critical for the understanding of mechanisms of cellular behavors. Petri Net, as a non-parametric approach, has been widely used for studying dynamics of a large scale of signaling network only based on the connections (interactions) within this network. In this article, we will describe an extension of the Petri net methods, called Enhanced Petri Net (EPN), specifcally designed for analyzing and modeling the dynamics of signaling pathways in order to predict the unknown signaling mechanisms of targeted-therapy drugs.

KW - ACM CCS→Computing methodologies→Modeling and simulation

KW - ACM CCS→Mathematics of computing→Discrete mathematics

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DO - 10.1515/itit-2013-1019

M3 - Article

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SN - 1611-2776

VL - 56

SP - 67

EP - 75

JO - IT - Information Technology

JF - IT - Information Technology

IS - 2

ER -

Enhanced Petri Net: Elucidating the pathway-level mechanism of targeted-therapy drugs

Abstract

Keywords

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