Enhanced Generation of Non-Oxygen Dependent Free Radicals by Schottky-type Heterostructures of Au-Bi 2 S 3 Nanoparticles via X-ray-Induced Catalytic Reaction for Radiosensitization

Xin Wang, Chenyang Zhang, Jiangfeng Du, Xinghua Dong, Shan Jian, Liang Yan, Zhanjun Gu, Yuliang Zhao

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


Despite the development of nanomaterials with high-Z elements for radiosensitizers, most of them suffer from their oxygen-dependent behavior in hypoxic tumor, nonideal selectivity to tumor, or inevasible damages to normal tissue, greatly limiting their further applications. Herein, we develop a Schottky-type heterostructure of Au-Bi2S3 with promising ability of reactive free radicals generation under X-ray irradiation for selectively enhancing radiotherapeutic efficacy by catalyzing intracellular H2O2 in tumor. On the one hand, like many other nanomaterials with rich high-Z elements, Au-Bi2S3 can deposit higher radiation dose within tumors in the form of high energy electrons. On the other hand, Au-Bi2S3 can remarkably improve the utilization of a large number of X-ray-induced low energy electrons during radiotherapy for nonoxygen dependent free radicals generation even in hypoxic condition. This feature of Schottky-type heterostructures Au-Bi2S3 attributes to the generated Schottky barrier between metal Au and semiconductor Bi2S3, which can trap the X-ray-generated electrons and transfer them to Au, resulting in efficient separation of the electron-hole pairs. Then, because of the matched potential between the conduction band of Bi2S3 and overexpressed H2O2 within tumor, the Au-Bi2S3 HNSCs can decompose the intracellular H2O2 into highly toxic OH for selective radiosensitization in tumor. As a consequence, this kind of nanoparticle provides an idea to develop rational designed Schottky-type heterostructures as efficient radiosensitizers for enhanced radiotherapy of cancer.

Original languageEnglish (US)
Pages (from-to)5947-5958
Number of pages12
JournalACS Nano
Issue number5
StatePublished - May 28 2019


  • Schottky junction
  • heterostructures
  • nanoparticles
  • radiosensitization
  • tumor microenvironment

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)


Dive into the research topics of 'Enhanced Generation of Non-Oxygen Dependent Free Radicals by Schottky-type Heterostructures of Au-Bi <sub>2</sub> S <sub>3</sub> Nanoparticles via X-ray-Induced Catalytic Reaction for Radiosensitization'. Together they form a unique fingerprint.

Cite this