Enhanced blood compatibility of silicon coated with a self-assembled poly(ethylene glycol) and monomethoxypoly(ethylene glycol)

Miqin Zhang, Mauro Ferrari

Research output: Contribution to journalConference article

9 Scopus citations

Abstract

Silicon biomedical microdevices generally require surface modifications to improve their biocompatibility. One of the challenges in the field is the development of molecular coatings for devices with nanofeatures. In this paper we report the results of our investigation of synthetic poly(ethylene glycol) (PEG) and monomethoxypoly(ethylene glycol) (MPEG) coatings incorporating functional groups that in turn immobilize self-assembled (SA) monolayers. The properties of the modified surfaces were characterized by ellipsometry and scanning electron microscopy (SEM). Protein adsorption as well as platelet adhesion to the treated surfaces were studied to evaluate the non-fouling property of the PEG-enriched surface layers. Both PEG- and MPEG-modified surfaces showed significant suppression in plasma protein adsorption and platelet adhesion.

Original languageEnglish (US)
Pages (from-to)15-19
Number of pages5
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume3258
DOIs
StatePublished - Dec 1 1998
EventMicro - and Nanofabricated Structures and Devices for Biomedical Environmental Applications - San Jose, CA, United States
Duration: Jan 26 1998Jan 27 1998

Keywords

  • PEG self-assembly monolayer
  • Platelet adhesion
  • Protein adsorption
  • Silicon
  • Surface modification

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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