Abstract
Silicon biomedical microdevices generally require surface modifications to improve their biocompatibility. One of the challenges in the field is the development of molecular coatings for devices with nanofeatures. In this paper we report the results of our investigation of synthetic poly(ethylene glycol) (PEG) and monomethoxypoly(ethylene glycol) (MPEG) coatings incorporating functional groups that in turn immobilize self-assembled (SA) monolayers. The properties of the modified surfaces were characterized by ellipsometry and scanning electron microscopy (SEM). Protein adsorption as well as platelet adhesion to the treated surfaces were studied to evaluate the non-fouling property of the PEG-enriched surface layers. Both PEG- and MPEG-modified surfaces showed significant suppression in plasma protein adsorption and platelet adhesion.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 15-19 |
| Number of pages | 5 |
| Journal | Proceedings of SPIE - The International Society for Optical Engineering |
| Volume | 3258 |
| DOIs | |
| State | Published - 1998 |
| Event | Micro - and Nanofabricated Structures and Devices for Biomedical Environmental Applications - San Jose, CA, United States Duration: Jan 26 1998 → Jan 27 1998 |
Keywords
- PEG self-assembly monolayer
- Platelet adhesion
- Protein adsorption
- Silicon
- Surface modification
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics
- Computer Science Applications
- Applied Mathematics
- Electrical and Electronic Engineering