Enhanced Activity of Polynuclear Aromatic Hydrocarbon Mixtures as Aryl Hydrocarbon (Ah) Receptor Agonists

Kathy Chaloupka, Nyla Harper, Venkatesh Krishnan, Michael Steinberg, Michael Santostefano, Stephen H. Safe, James Womack, Lewis V. Rodriguez, Harold A. Dunsford, Lawrence S. Goldstein

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The relative potencies of benzor[a]pyrene and a complex mixture of polycyclic aromatic hydrocarbons (PAH) produced as by-products of manufactured gas plant (MGP) residues as inducers of hepatic microsomal ethoxyresorufin O-deethylase (EROD) were determined in the B6C3F1mouse. The ED50 values for the induction response were 78 and 65 mg/kg for benzo[a]pyrene and the MGP-PAH mixture, respectively, although benzo[a]pyrene and other compounds containing four or more rings were only trace components of this mixture. A comparison of the EROD induction potencies of benzo[a]pyrene and the MGP-PAH mixture showed that the mixture was approximately 706 times more active than expected based on its benzo[a]pyrene content (0.17%). The enhanced activity of the MGP-PAH mixture was also observed for several other aryl hydrocarbon (Ah) receptor-mediated responses, including inhibition of the splenic plaque-forming cell (PFC) response to both T-cell-dependent and independent antigens in B6C3F1mice. The nature of these PAH interactions will be discussed.

Original languageEnglish (US)
Pages (from-to)191-198
Number of pages8
JournalPolycyclic Aromatic Compounds
Volume7
Issue number1-3
DOIs
StatePublished - Aug 1 1994
Externally publishedYes

Keywords

  • PAH
  • hepatic CYP1A1 induction

ASJC Scopus subject areas

  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

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