Engineering the assemblies of biomaterial nanocarriers for delivery of multiple theranostic agents with enhanced antitumor efficacy

Hai Wang; Yan Wu; Ruifang Zhao; Guangjun Nie

doi:10.1002/adma.201204750

Engineering the assemblies of biomaterial nanocarriers for delivery of multiple theranostic agents with enhanced antitumor efficacy

Hai Wang, Yan Wu, Ruifang Zhao, Guangjun Nie

Research output: Contribution to journal › Article › peer-review

98 Scopus citations

Abstract

The rapid development of nanotechnology holds great promise for revolutionizing the current landscape of tumor drug delivery. However, one of the biggest challenges is developing a simple nanocarrier platform to co-deliver various therapeutic agents. Here, a strategy for fabricating nanocarriers with many desirable features is demonstrated. The resulting nanoparticles achieve both high antitumor efficacy and effective inhibition of tumor metastasis with minimal side effects.

Original language	English (US)
Pages (from-to)	1616-1622
Number of pages	7
Journal	Advanced Materials
Volume	25
Issue number	11
DOIs	https://doi.org/10.1002/adma.201204750
State	Published - Mar 20 2013

Keywords

cancer metastasis
combination therapy
drug delivery
multifunctional nanoparticles

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.201204750

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AU - Wu, Yan

AU - Zhao, Ruifang

AU - Nie, Guangjun

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AB - The rapid development of nanotechnology holds great promise for revolutionizing the current landscape of tumor drug delivery. However, one of the biggest challenges is developing a simple nanocarrier platform to co-deliver various therapeutic agents. Here, a strategy for fabricating nanocarriers with many desirable features is demonstrated. The resulting nanoparticles achieve both high antitumor efficacy and effective inhibition of tumor metastasis with minimal side effects.

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KW - combination therapy

KW - drug delivery

KW - multifunctional nanoparticles

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Engineering the assemblies of biomaterial nanocarriers for delivery of multiple theranostic agents with enhanced antitumor efficacy

Abstract

Keywords

ASJC Scopus subject areas

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