Engineering Multifunctional DNA Hybrid Nanospheres through Coordination-Driven Self-Assembly

Mengyuan Li, Congli Wang, Zhenghan Di, Hui Li, Jingfang Zhang, Wenting Xue, Meiping Zhao, Ke Zhang, Yuliang Zhao, Lele Li

Research output: Contribution to journalArticlepeer-review

154 Scopus citations


Developing simple and general approaches for the synthesis of nanometer-sized DNA materials with specific morphologies and functionalities is important for various applications. Herein, a novel approach for the synthesis of a new set of DNA-based nanoarchitectures through coordination-driven self-assembly of Fe II ions and DNA molecules is reported. By fine-tuning the assembly, Fe–DNA nanospheres of precise sizes and controlled compositions can be produced. The hybrid nanoparticles can be tailored for delivery of functional DNA to cells in vitro and in vivo with enhanced biological function. This highlights the potential of metal ion coordination as a tool for directing the assembly of DNA architectures, which conceptualizes a new pathway to expand the repertoire of DNA-based nanomaterials. This methodology will advance both the fields of DNA nanobiotechnology and metal–ligand coordination chemistry.

Original languageEnglish (US)
Pages (from-to)1350-1354
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number5
StatePublished - Jan 28 2019


  • DNA nanobiotechnology
  • coordination polymer
  • hybrid materials
  • nanomedicine
  • self-assembly

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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