Engineering multicellular living systems—a Keystone Symposia report

Jennifer Cable, Paola Arlotta, Kevin Kit Parker, Alex J. Hughes, Katharine Goodwin, Christine L. Mummery, Roger D. Kamm, Sandra J. Engle, Danilo A. Tagle, Sylvia F. Boj, Alice E. Stanton, Yoshihiro Morishita, Melissa L. Kemp, Dennis A. Norfleet, Elebeoba E. May, Aric Lu, Rashid Bashir, Adam W. Feinberg, Sarah M. Hull, Anjelica L. GonzalezMichael R. Blatchley, Núria Montserrat Pulido, Ryuji Morizane, Todd C. McDevitt, Deepak Mishra, Adriana Mulero-Russe

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The ability to engineer complex multicellular systems has enormous potential to inform our understanding of biological processes and disease and alter the drug development process. Engineering living systems to emulate natural processes or to incorporate new functions relies on a detailed understanding of the biochemical, mechanical, and other cues between cells and between cells and their environment that result in the coordinated action of multicellular systems. On April 3–6, 2022, experts in the field met at the Keystone symposium “Engineering Multicellular Living Systems” to discuss recent advances in understanding how cells cooperate within a multicellular system, as well as recent efforts to engineer systems like organ-on-a-chip models, biological robots, and organoids. Given the similarities and common themes, this meeting was held in conjunction with the symposium “Organoids as Tools for Fundamental Discovery and Translation”.

Original languageEnglish (US)
Pages (from-to)183-195
Number of pages13
JournalAnnals of the New York Academy of Sciences
Issue number1
StatePublished - Dec 2022


  • computational
  • engineered living
  • engineered organs
  • multicellular
  • systems

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science


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