Engineering multi-stage nanovectors for controlled degradation andtunable release kinetics

Jonathan O. Martinez, Ciro Chiappini, Arturas Ziemys, Ari M. Faust, Milos Kojic, Xuewu Liu, Mauro Ferrari, Ennio Tasciotti

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Nanovectors hold substantial promise in abating the off-target effects of therapeutics by providing a means to selectively accumulate payloads at the target lesion, resulting in an increase in the therapeutic index. A sophisticated understanding of the factors that govern the degradation and release dynamics of these nanovectors is imperative to achieve these ambitious goals. In this work, we elucidate the relationship that exists between variations in pore size and the impact on the degradation, loading, and release of multistage nanovectors. Larger pored vectors displayed faster degradation and higher loading of nanoparticles, while exhibiting the slowest release rate. The degradation of these particles was characterized to occur in a multi-step progression where they initially decreased in size leaving the porous core isolated, while the pores gradually increased in size. Empirical loading and release studies of nanoparticles along with diffusion modeling revealed that this prolonged release was modulated by the penetration within the porous core of the vectors regulated by their pore size.

Original languageEnglish (US)
Pages (from-to)8469-8477
Number of pages9
JournalBiomaterials
Volume34
Issue number33
DOIs
StatePublished - Nov 2013

Keywords

  • Degradation
  • Drug delivery
  • Nanoparticle
  • Nanovector
  • Porosity
  • Porous silicon

ASJC Scopus subject areas

  • Biomaterials
  • Bioengineering
  • Ceramics and Composites
  • Mechanics of Materials
  • Biophysics

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