Engineering lipid tubules using nano-sized building blocks: The combinatorial self-assembly of vesicles

Yung Chieh Tan, Amy Q. Shen, Yu Li, Elliot Elson, Liang Ma

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Nano-sized lipid vesicles with tailored properties have been used as building blocks to generate lipid tubules between two glass surfaces. The tubules formed not only have defined orientation, width, and length, but they can also grow to be as long as 13 mm under ambient conditions, without externally supplied flow, temperature control, or catalyzing agents. Tubule membrane and its internal aqueous content can be manipulated by controlling the combination of different vesicle's lipid composition and aqueous entrapment. This self-assembly process opens up new pathways for generating complicated and flexible architectures for use in biocompatible molecular and supramolecular engineering. We demonstrated these possibilities by generating tubules encapsulated with siRNA, tubules with multiple branches, and polymerized fluorescent tubules in a single-throughput self-assembly process.

Original languageEnglish (US)
Pages (from-to)339-345
Number of pages7
JournalLab on a Chip
Volume8
Issue number2
DOIs
StatePublished - 2008

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

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