Engineered T cells for cancer treatment

Usanarat Anurathapan, Ann M. Leen, Malcolm K. Brenner, Juan F. Vera

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Adoptively transferred T cells have the capacity to traffic to distant tumor sites, infiltrate fibrotic tissue and kill antigen-expressing tumor cells. Various groups have investigated different genetic engineering strategies designed to enhance tumor specificity, increase T cell potency, improve proliferation, persistence or migratory capacity and increase safety. This review focuses on recent developments in T cell engineering, discusses the clinical application of these engineered cell products and outlines future prospects for this therapeutic modality.

Original languageEnglish (US)
Pages (from-to)713-733
Number of pages21
JournalCytotherapy
Volume16
Issue number6
DOIs
StatePublished - Jun 2014

Keywords

  • Cancer treatment
  • CAR T cells
  • Genetic modification of T cells
  • Immunotherapy

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Oncology
  • Genetics(clinical)
  • Transplantation
  • Cancer Research
  • Cell Biology

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