Abstract
Aim: Porphyrin-loaded core-shell nanoparticles have been engineered for use as in vivo sonosensitizing systems, radio-tracers or magnetic resonance (MR) imaging agents, which may be suitable for the selective treatment of solid tumors and imaging analyses. Materials & methods: Polymethyl methacrylate nanoparticles (PMMANPs) have been either loaded with meso-tetrakis (4-sulphonatophenyl) porphyrin (TPPS) for sonodynamic anticancer treatment, with 64Cu-TPPS for positron emission tomography biodistribution studies or with Mn(III)-TPPS for MR tumor accumulation evaluation. Results: PMMANPs are easily functionalized with negatively charged molecules and show favorable biodistribution. In vivo TPPS-PMMANPs have demonstrated shock wave responsiveness in a Mat B III syngeneic rat breast cancer model as measured by MR analyses of pre-and post-treatment tumor volumes. Conclusion: TPPS-PMMANPs are a multimodal system which can efficiently induce in vivo sonodynamic anticancer activity.
Original language | English (US) |
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Pages (from-to) | 3483-3494 |
Number of pages | 12 |
Journal | Nanomedicine |
Volume | 10 |
Issue number | 23 |
DOIs | |
State | Published - Dec 2015 |
Keywords
- acoustic cavitation
- cancer
- polymethyl methacrylate nanoparticles
- porphyrin
- reactive oxygen species
- shock waves
- sonodynamic therapy
- sonosensitizer
- theranostics
- therapeutic ultrasound
ASJC Scopus subject areas
- Bioengineering
- Medicine (miscellaneous)
- Biomedical Engineering
- Materials Science(all)