Energy translocation across cell membranes and membrane models

Henry J. Pownall, J. A. Hamilton

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Fatty acid transport is an important process in cellular energy distribution and storage in both normal and pathological states, especially obesity-linked type 2 diabetes mellitus. Fatty acid transport has been studied by the complementary approaches of cell biology and biophysics. According to the latter approach, specific proteins that enhance the uptake and storage of fatty acids are posited as fatty acid translocases, which facilitate fatty acid movement from the outer to inner leaflets of the plasma membrane. According to biophysical studies conducted in vitro, fatty acid translocation occurs by a rapid diffusive process that does not require a protein. Herein, we critically review these two mechanisms and their importance in the regulation of fatty acid uptake in vivo.

Original languageEnglish (US)
Pages (from-to)357-365
Number of pages9
JournalActa Physiologica Scandinavica
Volume178
Issue number4
DOIs
StatePublished - Aug 1 2003
Externally publishedYes

Keywords

  • Adipogenesis
  • Fatty acid
  • Flip-flop
  • Metabolism

ASJC Scopus subject areas

  • Physiology

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