Endovascular shear strain elastography for the detection and characterization of the severity of atherosclerotic plaques: In vitro validation and in vivo evaluation

Younes Majdouline, Jacques Ohayon, Zahra Keshavarz-Motamed, Marie Hélène Roy Cardinal, Damien Garcia, Louise Allard, Sophie Lerouge, Frédéric Arsenault, Gilles Soulez, Guy Cloutier

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

This work explores the potential of shear strain elastograms to identify vulnerable atherosclerotic plaques. The Lagrangian speckle model estimator (LSME) elasticity imaging method was further developed to estimate shear strain elasticity (SSE). Three polyvinyl alcohol cryogel vessel phantoms were imaged with an intravascular ultrasound (IVUS) scanner. The estimated SSE maps were validated against finite-element results. Atherosclerosis was induced in carotid arteries of eight Sinclair mini-pigs using a combination of surgical techniques, diabetes and a high-fat diet. IVUS images were acquired invivo in 14 plaques before euthanasia and histology. All plaques were characterized by high magnitudes in SSE maps that correlated with American Heart Association atherosclerosis stage classifications (r=0.97, p<0.001): the worse the plaque condition the higher was the absolute value of SSE, i.e. |SSE| (e.g., mean |SSE| was 3.70±0.40% in Type V plaques, whereas it was reduced to 0.11±0.01% in normal walls). This study indicates the feasibility of using SSE to highlight atherosclerotic plaque vulnerability characteristics.

Original languageEnglish (US)
Pages (from-to)890-903
Number of pages14
JournalUltrasound in Medicine and Biology
Volume40
Issue number5
DOIs
StatePublished - May 2014

Keywords

  • Atherosclerotic plaque image processing
  • Intravascular ultrasound
  • Shear strain
  • Swine model
  • Vascular elastography
  • Vulnerable plaques

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics

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