Endothelium-Derived Nitric Oxide as an Antiatherogenic Mechanism: Implications for Therapy

Roman A Sukhovershin, Gautham Yepuri, Yohannes T Ghebremariam

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Endothelium-derived nitric oxide (eNO) is a multifunctional signaling molecule critically involved in the maintenance of metabolic and cardiovascular homeostasis. In addition to its role as a potent endogenous vasodilator, eNO suppresses key processes in vascular lesion formation and opposes atherogenesis. This review discusses eNO as an antiatherogenic molecule and highlights factors that influence its bioavailability and therapeutic approaches to restore or enhance its levels.

Original languageEnglish (US)
Pages (from-to)166-71
Number of pages6
JournalMethodist DeBakey cardiovascular journal
Volume11
Issue number3
DOIs
StatePublished - Dec 4 2015

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