Endothelium-Derived Nitric Oxide as an Antiatherogenic Mechanism: Implications for Therapy

Roman A Sukhovershin; Gautham Yepuri; Yohannes T Ghebremariam

doi:10.14797/mdcj-11-3-166

Endothelium-Derived Nitric Oxide as an Antiatherogenic Mechanism: Implications for Therapy

Roman A Sukhovershin, Gautham Yepuri, Yohannes T Ghebremariam

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Abstract

Endothelium-derived nitric oxide (eNO) is a multifunctional signaling molecule critically involved in the maintenance of metabolic and cardiovascular homeostasis. In addition to its role as a potent endogenous vasodilator, eNO suppresses key processes in vascular lesion formation and opposes atherogenesis. This review discusses eNO as an antiatherogenic molecule and highlights factors that influence its bioavailability and therapeutic approaches to restore or enhance its levels.

Original language	English (US)
Pages (from-to)	166-71
Number of pages	6
Journal	Methodist DeBakey cardiovascular journal
Volume	11
Issue number	3
DOIs	https://doi.org/10.14797/mdcj-11-3-166
State	Published - Dec 4 2015

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abstract = "Endothelium-derived nitric oxide (eNO) is a multifunctional signaling molecule critically involved in the maintenance of metabolic and cardiovascular homeostasis. In addition to its role as a potent endogenous vasodilator, eNO suppresses key processes in vascular lesion formation and opposes atherogenesis. This review discusses eNO as an antiatherogenic molecule and highlights factors that influence its bioavailability and therapeutic approaches to restore or enhance its levels.",

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AB - Endothelium-derived nitric oxide (eNO) is a multifunctional signaling molecule critically involved in the maintenance of metabolic and cardiovascular homeostasis. In addition to its role as a potent endogenous vasodilator, eNO suppresses key processes in vascular lesion formation and opposes atherogenesis. This review discusses eNO as an antiatherogenic molecule and highlights factors that influence its bioavailability and therapeutic approaches to restore or enhance its levels.

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Endothelium-Derived Nitric Oxide as an Antiatherogenic Mechanism: Implications for Therapy

Abstract

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