Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis

Research output: Contribution to journalArticle

Dingcheng Gao, Daniel J. Nolan, Albert S. Mellick, Kathryn Bambino, Kevin McDonnell, Vivek Mittal

Angiogenesis-mediated progression of micrometastasis to lethal macrometastasis is the major cause of death in cancer patients. Here, using mouse models of pulmonary metastasis, we identify bone marrow (BM)-derived endothelial progenitor cells (EPCs) as critical regulators of this angiogenic switch. We show that tumors induce expression of the transcription factor Id1 in the EPCs and that suppression of Id1 after metastatic colonization blocked EPC mobilization, caused angiogenesis inhibition, impaired pulmonary macrometastases, and increased survival of tumor-bearing animals. These findings establish the role of EPCs in metastatic progression in preclinical models and suggest that selective targeting of EPCs may merit investigation as a therapy for cancer patients with lung metastases.

Original languageEnglish
Pages (from-to)195-198
Number of pages4
JournalScience
Volume319
Issue number5860
DOIs
StatePublished - Jan 11 2008

PMID: 18187653

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Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis. / Gao, Dingcheng; Nolan, Daniel J.; Mellick, Albert S.; Bambino, Kathryn; McDonnell, Kevin; Mittal, Vivek.

In: Science, Vol. 319, No. 5860, 11.01.2008, p. 195-198.

Research output: Contribution to journalArticle

Harvard

Gao, D, Nolan, DJ, Mellick, AS, Bambino, K, McDonnell, K & Mittal, V 2008, 'Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis' Science, vol. 319, no. 5860, pp. 195-198. https://doi.org/10.1126/science.1150224

APA

Gao, D., Nolan, D. J., Mellick, A. S., Bambino, K., McDonnell, K., & Mittal, V. (2008). Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis. Science, 319(5860), 195-198. https://doi.org/10.1126/science.1150224

Vancouver

Gao D, Nolan DJ, Mellick AS, Bambino K, McDonnell K, Mittal V. Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis. Science. 2008 Jan 11;319(5860):195-198. https://doi.org/10.1126/science.1150224

Author

Gao, Dingcheng ; Nolan, Daniel J. ; Mellick, Albert S. ; Bambino, Kathryn ; McDonnell, Kevin ; Mittal, Vivek. / Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis. In: Science. 2008 ; Vol. 319, No. 5860. pp. 195-198.

BibTeX

@article{e17dee6312944e55a0898f6a76732754,
title = "Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis",
abstract = "Angiogenesis-mediated progression of micrometastasis to lethal macrometastasis is the major cause of death in cancer patients. Here, using mouse models of pulmonary metastasis, we identify bone marrow (BM)-derived endothelial progenitor cells (EPCs) as critical regulators of this angiogenic switch. We show that tumors induce expression of the transcription factor Id1 in the EPCs and that suppression of Id1 after metastatic colonization blocked EPC mobilization, caused angiogenesis inhibition, impaired pulmonary macrometastases, and increased survival of tumor-bearing animals. These findings establish the role of EPCs in metastatic progression in preclinical models and suggest that selective targeting of EPCs may merit investigation as a therapy for cancer patients with lung metastases.",
author = "Dingcheng Gao and Nolan, {Daniel J.} and Mellick, {Albert S.} and Kathryn Bambino and Kevin McDonnell and Vivek Mittal",
year = "2008",
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day = "11",
doi = "10.1126/science.1150224",
language = "English",
volume = "319",
pages = "195--198",
journal = "Science (New York, N.Y.)",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5860",

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RIS

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T1 - Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis

AU - Gao, Dingcheng

AU - Nolan, Daniel J.

AU - Mellick, Albert S.

AU - Bambino, Kathryn

AU - McDonnell, Kevin

AU - Mittal, Vivek

PY - 2008/1/11

Y1 - 2008/1/11

N2 - Angiogenesis-mediated progression of micrometastasis to lethal macrometastasis is the major cause of death in cancer patients. Here, using mouse models of pulmonary metastasis, we identify bone marrow (BM)-derived endothelial progenitor cells (EPCs) as critical regulators of this angiogenic switch. We show that tumors induce expression of the transcription factor Id1 in the EPCs and that suppression of Id1 after metastatic colonization blocked EPC mobilization, caused angiogenesis inhibition, impaired pulmonary macrometastases, and increased survival of tumor-bearing animals. These findings establish the role of EPCs in metastatic progression in preclinical models and suggest that selective targeting of EPCs may merit investigation as a therapy for cancer patients with lung metastases.

AB - Angiogenesis-mediated progression of micrometastasis to lethal macrometastasis is the major cause of death in cancer patients. Here, using mouse models of pulmonary metastasis, we identify bone marrow (BM)-derived endothelial progenitor cells (EPCs) as critical regulators of this angiogenic switch. We show that tumors induce expression of the transcription factor Id1 in the EPCs and that suppression of Id1 after metastatic colonization blocked EPC mobilization, caused angiogenesis inhibition, impaired pulmonary macrometastases, and increased survival of tumor-bearing animals. These findings establish the role of EPCs in metastatic progression in preclinical models and suggest that selective targeting of EPCs may merit investigation as a therapy for cancer patients with lung metastases.

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U2 - 10.1126/science.1150224

DO - 10.1126/science.1150224

M3 - Article

VL - 319

SP - 195

EP - 198

JO - Science (New York, N.Y.)

T2 - Science (New York, N.Y.)

JF - Science (New York, N.Y.)

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ID: 2582039